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Titre du document / Document title

Prostaglandin E2 decreases fetal breathing movements, but not pulmonary blood flow, in fetal sheep

Auteur(s) / Author(s)

SAVICH R. D. ; GUERRA F. A. ; LEE C.-C. H. ; KITTERMAN J. A. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. California, cardiovascular res. inst. and dep. pediatrics, San Francisco CA 94143, ETATS-UNIS

Résumé / Abstract

Fetal breathing movements are vital for normal fetal lung growth. Inhibition of these fetal breathing movements is associated with pulmonary hypoplasia. Pulmonary hypoplasia also occurs subsequent to alterations in other factors, such as a significant decrease in pulmonary blood flow. The prostaglandin system is known to have profound effects on both fetal breathing movements and on the pulmonary vascular system. We studied six late-gestation chronically instrumented fetal sheep by using an electromagnetic flow transducer around the left pulmonary artery to determine whether a decrease in fetal breathing movements, subsequent to a continuous infusion of prostaglandin E2 (PGE2), is associated with a decrease in pulmonary blood flow. A continuous PGE2 infusion of 0.88±0.11 μg.kg-1.min-1 over 120 min led to a significant decrease in fetal breathing movements (control 40.5±3.6%, infusion 3.3±1.6%; P<0.001). In contrast, the PGE2 infusion had no effect on mean left pulmonary artery blood flow (control 27.7±9.3 ml.min-1.kg-1, infusion 23.8±7.0 ml.min-1.kg-1. The PGE2 infusion demonstrated central effects in the percentage of time the fetus was in high-voltage electrocortical activity (control 41.9±2.5%, infusion 56.5±5.4%; P<0.05) and in the amount of time spent in low-voltage electrocortical activity without fetal breathing movements (control 17.5±2.7%, infusion 40.2±4.8%; P<0.05). A significant decrease in the fetal heart rate during the infusion was seen with no effect on either the systemic or pulmonary blood pressure. Thus it appears unlikely that the changes seen in lung growth subsequent to an absence of fetal breathing movements are mediated via changes in pulmonary blood flow

Revue / Journal Title

Journal of applied physiology    ISSN  8750-7587   CODEN JAPHEV 

Source / Source

1995, vol. 78, no4, pp. 1477-1484 (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Physiological Society, Bethesda, MD, ETATS-UNIS  (1985) (Revue)

Mots-clés anglais / English Keywords

Fetus

;

Regional blood flow

;

Lung

;

Respiratory movement

;

Prostaglandin E2

;

Pulmonary circulation

;

Sheep

;

Hemodynamics

;

Respiratory system

;

Respiration

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Mots-clés français / French Keywords

Foetus

;

Débit sanguin régional

;

Poumon

;

Mouvement respiratoire

;

Prostaglandine E2

;

Circulation pulmonaire

;

Mouton

;

Hémodynamique

;

Appareil respiratoire

;

Respiration

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Mots-clés espagnols / Spanish Keywords

Feto

;

Flujo sanguíneo regional

;

Pulmón

;

Movimiento respiratorio

;

Prostaglandina E2

;

Circulación pulmonar

;

Carnero

;

Hemodinámica

;

Aparato respiratorio

;

Respiración

;

Artiodactyla

;

Ungulata

;

Mammalia

;

Vertebrata

;

Localisation / Location

INIST-CNRS, Cote INIST : 5400, 35400005684981.0350

Nº notice refdoc (ud4) : 3523714



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