Titre du document / Document title

Overview of the use of terbinafine (Lamisil®) in children

Auteur(s) / Author(s)

JONES T. C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Sandoz Pharma Ltd, clin. res. cent., Basle 4002, SUISSE

Résumé / Abstract

This review summarizes the efficacy and tolerability of terbinafine (Lamisil®) in the treatment of dermatophytoses in children. In six clinical studies, 1 52 children who received terbinafine were evaluable for efficacy and 196 were evaluable for tolerability. In these studies, terbinafine was used for between 1 and 28 weeks. The median treatment was 4 weeks, the duration of treatment in the tinea capitis studies. As a result of extensive experience in adults at doses of 10 mg/kg and less, and the overall pharmacokinetic profile in children, including the lower volume of distribution of terbinafine into lipophilic tissue, the use of a dose of 125 mg/day for children weighing 20-40 kg, and 62-5 mg/day in children weighing less than 20 kg, has been proposed. This dose was shown to be well tolerated and effective. For children weighing >40 kg, the adult dose of 2 50 mg is appropriate. Terbinafine was shown to be very effective (93% cured), in the treatment of children with tinea capitis, using a shorter treatment duration (4 weeks) than that usually employed with presently available antifungal drugs. It is also effective in children with various dermatophyte infections of the skin, with a cure rate of more than 90%. Terbinafine was shown to be well tolerated in children aged between 2 and 17 years. The recommended duration of treatment for tinea capitis is 4 weeks. The recommended duration of treatment for other skin or nail dermatophyte infections, based on extensive studies in adults, and confirmed in children, is 2 weeks for tinea corporis and tinea pedis, 6 weeks for finger-nail onychomycosis and 12 weeks for toe-nail onychomycosis

Revue / Journal Title

British journal of dermatology   ISSN 0007-0963   CODEN BJDEAZ 

Source / Source

1995, vol. 132, n^o5, pp. 683-689 (10 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1951) (Revue)

Mots-clés anglais / English Keywords

Antifungal agent ; Child ; Mycosis ; Scalp ; Treatment efficiency ; Allylic compound ; Amine ; Human ; Infection ;

Mots-clés français / French Keywords

Terbinafine ; Antifongique ; Enfant ; Mycose ; Cuir chevelu ; Efficacité traitement ; Composé allylique ; Amine ; Homme ; Infection ;

Mots-clés espagnols / Spanish Keywords

Antifúngico ; Niño ; Micosis ; Cuero cabelludo ; Eficacia tratamiento ; Compuesto alílico ; Amina ; Hombre ; Infección ;

Localisation / Location

INIST-CNRS, Cote INIST : 1043, 35400005703294.0020