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Titre du document / Document title

Screening of various plant extracts used in Ayurvedic medicine for inhibitory effects on human immunodeficiency virus type 1 (HIV-1) protease

Auteur(s) / Author(s)

KUSUMOTO I. T. (1) ; NAKABAYASHI T. (1) ; KIDA H. (1) ; MIYASHIRO H. (1) ; HATTORI M. (1) ; NAMBA T. (1) ; SHIMOTOHNO K. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Toyama medical pharmaceutical univ., res. inst. Wakan-Yaku, Toyama 930-01, JAPON

Résumé / Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity in traditional medicines, water and methanol extracts of crude drugs used in Indian traditional medicine (Ayurveda) were subjected to screening for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC and of the 39 crude drugs tested, the extracts of the seeds of Areca catechu, the bark of Eugenia jambolana, the bark of Saraca indica and the stem bark of Terminalia arjuna inhibited the HIV-1 PR activity by more than 70% at a concentration of 0.2 mg/mL. The most potent inhibition was shown by the A. catechu extract, from which some procyanidins were isolated. One of them, arecatannin B1 showed significant HIV-1-PR inhibitory activity

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

1995, vol. 9, no3, pp. 180-184 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Plant origin

;

Medicinal plant

;

Folk medicine

;

Human immunodeficiency virus

;

Proteinases

;

Pharmacognosy

;

Extract

;

India

;

Enzymatic activity

;

In vitro

;

Biological activity

;

Lentivirinae

;

Retroviridae

;

Virus

;

Hydrolases

;

Enzyme

;

Asia

;

Mots-clés français / French Keywords

Origine végétale

;

Plante médicinale

;

Médecine traditionnelle

;

Virus immunodéficience humaine

;

Proteinases

;

Pharmacognosie

;

Extrait

;

Inde

;

Activité enzymatique

;

In vitro

;

Activité biologique

;

Ayurveda

;

Areca catechu

;

Lentivirinae

;

Retroviridae

;

Virus

;

Hydrolases

;

Enzyme

;

Asie

;

Mots-clés espagnols / Spanish Keywords

Origen vegetal

;

Planta medicinal

;

Medicina tradicional

;

Human immunodeficiency virus

;

Proteinases

;

Farmacognosia

;

Extracto

;

India

;

Actividad enzimática

;

In vitro

;

Actividad biológica

;

Lentivirinae

;

Retroviridae

;

Virus

;

Hydrolases

;

Enzima

;

Asia

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400005679981.0040

Nº notice refdoc (ud4) : 3499215



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