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Titre du document / Document title

Effect of a mixture of 15 commonly used pesticides on DNA levels of 8-hydroxy-2-deoxyguanosine and xenobiotic metabolizing enzymes in rat liver

Auteur(s) / Author(s)

LODOVICI M. (1) ; AIOLLI S. (1) ; MONSERRAT C. (1) ; DOLARA P. (1) ; MEDICA A. (1) ; DI SIMPLICIO P. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Univ. Florence, dep. pharmacology toxicology, 50134 Florence, ITALIE
(2) Univ. Siena, dep. environmental biology, ITALIE

Résumé / Abstract

The level of 8-OH-2-deoxyguanosine in rat liver DNA was measured as an index of oxidative damage after treating rats for 10 days at a dose ranging from 0.75 to 10 mg/kg with a mixture of 15 pesticides (dithiocarbamate, benomyl, thiabendazole, diphenylamine, chlorthalonil, procimidone, methidathion, chlorpyrifos-ethyl, fenarimol, parathion-methyl, chlorpropham, parathion, vinclozolin, chlorfenvinphos, pirimiphos-ethyl) commonly found in foods of central Italy. At the doses of 0.75 and 1 mg/kg DNA levels of 8-OH-2-deoxyguanosine were significantly increased relative to controls, whereas at higher doses (2.5, 5, 10 mg/kg) the levels returned to control values. The administration of the pesticide mixture dose dependently reduced benzo(a)pyrene hydroxylase, N-demethylase activities, glutathione peroxidase, glutathione reductase, glutathione-S-transferase and thiol transferase activities in the liver. The results show that the pesticide mixture induced free radical DNA damage at low doses. However, at higher doses it produced a depression of cellular metabolism, inhibiting a further expression of oxidative damage

Revue / Journal Title

Journal of environmental pathology, toxicology and oncology    ISSN  0731-8898   CODEN JEPOEC 

Source / Source

1994, vol. 13, no3, pp. 163-168 (21 ref.)

Langue / Language

Anglais

Editeur / Publisher

Begell House, New York, NY, ETATS-UNIS  (1984) (Revue)

Mots-clés anglais / English Keywords

Pesticides

;

Toxic association

;

Toxicity

;

Rat

;

Animal

;

Liver

;

Residue

;

Food

;

Drug-metabolizing enzyme

;

DNA

;

Enzymatic activity

;

Oral administration

;

Oxidation

;

Rodentia

;

Mammalia

;

Vertebrata

;

Enzyme

;

Digestive diseases

;

Mots-clés français / French Keywords

Pesticide

;

Association toxique

;

Toxicité

;

Rat

;

Animal

;

Foie

;

Résidu

;

Aliment

;

Drug-metabolizing enzyme

;

DNA

;

Activité enzymatique

;

Voie orale

;

Oxydation

;

Rodentia

;

Mammalia

;

Vertebrata

;

Enzyme

;

Appareil digestif pathologie

;

Mots-clés espagnols / Spanish Keywords

Plaguicida

;

Asociación toxíca

;

Toxicidad

;

Rata

;

Animal

;

Hígado

;

Resíduo

;

Alimento

;

Drug-metabolizing enzyme

;

DNA

;

Actividad enzimática

;

Vía oral

;

Oxidación

;

Rodentia

;

Mammalia

;

Vertebrata

;

Enzima

;

Aparato digestivo patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 18066, 35400005635181.0020

Nº notice refdoc (ud4) : 3483984



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