Titre du document / Document title

Acyclovir-induced renal failure in the treatment of presumed viral retinitis

Auteur(s) / Author(s)

LOPEZ P. F. ⁽¹⁾ ; DAVIS J. L. ; PARE R. ; KINOTA S. ; LAMBERT H. M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Univ. southern California school medicine, Doheny eye inst., Los Angeles CA 90033, ETATS-UNIS

Résumé / Abstract

Seven university teaching hospitals or retina subspecialty clinics with published experience in the treatment of viral retinitis were surveyed to identify cases of acyclovir-induced nephrotoxicity. Four patients from three university teaching hospitals were identified. These four patients, who were presumed to have viral retinitis and normal renal function, developed acute oliguric renal failure between 48 and 72 hours after the initiation of high-dose (500 mg/m² or 10 mg/kg every eight hours) intravenous acyclovir. Peak serum creatinine concentrations ranged from 3.4 mg/dL to 7 mg/dL. In three of the four patients, renal function returned to normal between four and seven days after discontinuation of the acyclovir. Reduced dosage of either intravenous or oral acyclovir was not associated with recrudescence of the acute renal failure in any of these three patients. The authors' findings suggest that renal function should be monitored routinely in patients receiving high-dose intravenous acyclovir for the treatment of presumed viral retinitis and that reduction of the acyclovir dose frequently results in resolution of the acute renal failure despite continued treatment of the viral retinitis

Revue / Journal Title

Annals of ophthalmology   ISSN 0003-4886   CODEN ANOPB5 

Source / Source

1995, vol. 27, n^o2, pp. 75-84 (25 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Society of Contemporary Medicine, Surgery and Ophtalmology, Madison, CT, ETATS-UNIS  (1969-1994) (Revue)

Mots-clés anglais / English Keywords

Retinitis ; Viral disease ; Antiviral ; Chemotherapy ; Toxicity ; Renal failure ; Intravenous administration ; Human ; Acyclic nucleoside ; Purine nucleoside ; Infection ; Eye disease ; Retinopathy ; Urinary system disease ; Renal disease ; Nephropathy ;

Mots-clés français / French Keywords

Rétinite ; Virose ; Aciclovir ; Antiviral ; Chimiothérapie ; Toxicité ; Insuffisance rénale ; Voie intraveineuse ; Homme ; Nucléoside acyclique ; Purine nucléoside ; Infection ; Oeil pathologie ; Rétinopathie ; Appareil urinaire pathologie ; Rein pathologie ; Néphropathie ;

Mots-clés espagnols / Spanish Keywords

Retinitis ; Virosis ; Antiviral ; Quimioterapia ; Toxicidad ; Insuficiencia renal ; Vía intravenosa ; Hombre ; Nucleósido acíclico ; Purina nucleósido ; Infección ; Ojo patología ; Retinopatía ; Aparato urinario patología ; Riñón patología ; Nefropatía ;

Localisation / Location

INIST-CNRS, Cote INIST : 15454, 35400005614764.0030