RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Cardiovascular active substances from the straw mushroom, Volvariella volvacea

Auteur(s) / Author(s)

CHIU K. W. (1) ; LAM A. H. W. (1) ; PANG P. K. T. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Chinese univ. Hong Kong, dep. biology, Hong Kong, HONG-KONG

Résumé / Abstract

The straw mushroom Volvariella volvacea is one of the common edible mushrooms in Hong Kong and is widely cultivated in Southeast Asian countries. It has been reported to produce a hypotensive response in animals including humans. An aqueous extract of the mushroom (SME) was prepared and given through intravenous injections to normotensive rats. The blood pressure changes produced by SME alone or in the presence of various drugs were studied. The effects of SME on the kidney function of water-loaded rats and on isolated tissue preparations of the tail artery and right atrium were examined. An i.v. injection of SME produced a hypotensive effect in rats with an ED50 of 25 mg dry weight/kg body weight. This hypotensive effect of SME was attenuated or blunted in the presence of hexamethonium, phentolamine, pyrilamine and cimetidine suggesting the involvement of the α-adrenergic component of the autonomic system and/or histamineergic stimulation. SME did not increase urinary excretion nor sodium diuresis. It produced positive chronotropic and inotropic effects on isolated right atria and induced contraction of isolated tail artery strips. This latter contractile response was inhibited by antagonists of serotonin and α-adrenoceptor, ketanserin and phentolamine respectively. Partial purification using dialysis and liquid chromatography revealed that the hypotensive active substances had molecular masses between 8000 and 12000 dalton. These substances were heat stable and resistant to trypsin digestion. In view of the similarity in blood pressure and cardiovascular response, SME might contain serotonin-like substances

Revue / Journal Title

PTR. Phytotherapy research    ISSN  0951-418X 

Source / Source

1995, vol. 9, no2, pp. 93-99 (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wiley, Chichester, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Plant origin

;

Edible fungi

;

Biological activity

;

Arterial hypotension

;

Intravenous administration

;

Hypotensive drug

;

Animal

;

Rat

;

Mechanism of action

;

Arterial pressure

;

Renal function

;

Medicinal plant

;

Pharmacognosy

;

Circulatory system

;

Volvariella volvacea

;

Hong Kong

;

Rodentia

;

Mammalia

;

Vertebrata

;

Cardiovascular disease

;

Basidiomycetes

;

Fungi

;

Thallophyta

;

Asia

;

Mots-clés français / French Keywords

Origine végétale

;

Champignon comestible

;

Activité biologique

;

Hypotension artérielle

;

Voie intraveineuse

;

Hypotenseur

;

Animal

;

Rat

;

Mécanisme action

;

Pression artérielle

;

Fonction rénale

;

Plante médicinale

;

Pharmacognosie

;

Appareil circulatoire

;

Volvariella volvacea

;

Hong Kong

;

Rodentia

;

Mammalia

;

Vertebrata

;

Appareil circulatoire pathologie

;

Basidiomycetes

;

Fungi

;

Thallophyta

;

Asie

;

Mots-clés espagnols / Spanish Keywords

Origen vegetal

;

Hongo comestible

;

Actividad biológica

;

Hipotensión arterial

;

Vía intravenosa

;

Hipotensor

;

Animal

;

Rata

;

Mecanismo acción

;

Presión arterial

;

Función renal

;

Planta medicinal

;

Farmacognosia

;

Aparato circulatorio

;

Volvariella volvacea

;

Hong Kong

;

Rodentia

;

Mammalia

;

Vertebrata

;

Aparato circulatorio patología

;

Basidiomycetes

;

Fungi

;

Thallophyta

;

Asia

;

Localisation / Location

INIST-CNRS, Cote INIST : 21695, 35400005579165.0020

Nº notice refdoc (ud4) : 3462911



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas