RefDoc
Haut

Faire une nouvelle recherche
Make a new search
Lancer la recherche


Titre du document / Document title

Effects of magnesium on the renin-angiotensin-aldosterone system in human subjects

Auteur(s) / Author(s)

ICHIHARA A. ; SUZUKI H. ; SARUTA T. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Keio univ., school medicine, dep. internal medicine, Shinjuku-ku Tokyo 160, JAPON

Résumé / Abstract

Recent prospective study of intravenous magnesium sulphate administration into patients with acute myocardial infarction revealed the improvement of survival rate of these patients. This study was designed to determine the effect of intravenous administration of magnesium on the renin-angiotensin-aldosterone (RAA) system. MgSO4 (0.72% in 3.24% glucose solution) at 5 mEq/hr was infused intravenously into six healthy normotensive men for six hours. MgSO4 infusion increased plasma renin activity (PRA) at 60 minutes (4.1 ± 1.4 ng/ml/hr vs 2.7 ± 0.8 ng/ml/hr, p < 0.05) and decreased plasma aldosterone concentration (PAC) at 180 minutes (40 ± 8 pg/ml vs 60 ± 12 pg/ml, p < 0.05). The maximum level of serum magnesium reached 2.32 ± 0.09 mEq/L, from the control value of 1.58 ± 0.07 mEq/L, at 3 hours. Analysis of both serum levels and urinary excretion of electrolytes revealed significant increases in urinary excretion of calcium and magnesium, whereas no significant changes in other electrolytes in serum or urinary excretion were found. To clarify the mechanism by which magnesium increased PRA and suppressed PAC, either prostaglandin synthesis inhibitor, indomethacin (75 mg/day), or a calcium channel blocker, diltiazem (90 mg/day), was administered. Indomethacin completely blocked the increase in PRA but did not induce any changes in PAC. Diltiazem inhibited the decrease in PAC but did not induce any changes in PRA. These data indicate that magnesium stimulates renin release through the elevation of prostaglandins and suppresses aldosterone production through the intracellular calcium mobilization. From these results it is suggested that a favorable effect of magnesium administration to patients with myocardial infarction relates to the alterations of the RAA system

Revue / Journal Title

The Journal of laboratory and clinical medicine    ISSN  0022-2143   CODEN JLCMAK 

Source / Source

1993, vol. 122, no4, pp. 432-440 (38 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, St. Louis, MO, ETATS-UNIS  (1915-2006) (Revue)

Mots-clés anglais / English Keywords

Renin angiotensin aldosterone system

;

Human

;

Magnesium sulfate

;

Biological effect

;

Intravenous administration

;

Experimental study

;

Mechanism of action

;

Infarct

;

Myocardium

;

Treatment

;

Chemotherapy

;

Cardiovascular disease

;

Coronary heart disease

;

Myocardial disease

;

Mots-clés français / French Keywords

Système renin angiotensine aldostérone

;

Homme

;

Magnésium sulfate

;

Effet biologique

;

Voie intraveineuse

;

Etude expérimentale

;

Mécanisme action

;

Infarctus

;

Myocarde

;

Traitement

;

Chimiothérapie

;

Appareil circulatoire pathologie

;

Cardiopathie coronaire

;

Myocarde pathologie

;

Mots-clés espagnols / Spanish Keywords

Sistema renin angiotensina aldosterona

;

Hombre

;

Magnesio sulfato

;

Efecto biológico

;

Vía intravenosa

;

Estudio experimental

;

Mecanismo acción

;

Infarto

;

Miocardio

;

Tratamiento

;

Quimioterapia

;

Aparato circulatorio patología

;

Cardiopatía coronaria

;

Miocardio patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 2060, 35400005987038.0110

Nº notice refdoc (ud4) : 3445509



Faire une nouvelle recherche
Make a new search
Lancer la recherche
Bas