Titre du document / Document title

Experimental transplantation of hydroxylapatite-bone composite grafts. Discussion

Auteur(s) / Author(s)

SCHLIEPHAKE H. ⁽¹⁾ ; WILHELM NEUKAM F. ; HUTMACHER D. ; WÜSTENFELD H. ; MOHAMED SHARAWY (Commentateur) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Medzinische Hochschule Hannover, dep. oral maxillofacial surgery, 30625 Hannover, ALLEMAGNE

Résumé / Abstract

Purpose: This study was undertaken to determine if autogenous bone can be cultivated in vivo in a porous hydroxylapatite (HA) matrix by ingrowth from underlying bone and if this autogenous HA-bone composite graft can then be transplanted. Patients and Methods: Five Göttingen minipigs received subperiosteal implantation of one HA block each (40×10×10 mm), covered by a polylactic membrane, on the ascending ramus of the mandible. After 5 months, half of each implant was harvested and transplanted as an onlay graft to the horizontal ramus of the mandible with simultaneous insertion of a titanium implant. Polychrome fluorescence labeling was done 1, 2, 4, and 8 weeks postoperatively. After 3 months, the vascular system of the animals was filled with BaSO₄ for microangiographic examination, and all blocks were retrieved. Results: Fluorescence microscopy showed that there was a significant decrease in deposition of the label in the grafted blocks at 1 week when compared with later labels. After the second week, there were no significant changes. A 20% to 30% decrease in the frequency of fluorochrome staining was noted in the upper third of each block. In this region, microangiography demonstrated highly vascularized tissue and limited bone resorption. Conclusion: It was concluded that cultivation of mandibular bone in a porous matrix under guided bone regeneration is possible and that this autogenous HA-bone composite graft can be transplanted at a later date

Revue / Journal Title

Journal of oral and maxillofacial surgery   ISSN 0278-2391   CODEN JOMSDA 

Source / Source

1995, vol. 53, n^o1, pp. 46-52 (36 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1982) (Revue)

Mots-clés anglais / English Keywords

Composite flap ; Hydroxyapatite ; Surgery ; Technique ; Minipig ; Fluorescence microscopy ; Exploration ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Stomatology ;

Mots-clés français / French Keywords

Lambeau composite ; Apatite hydroxylée ; Chirurgie ; Technique ; Porc miniature ; Microscopie fluorescence ; Exploration ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Stomatologie ;

Mots-clés espagnols / Spanish Keywords

Colgajo compuesto ; Hidroxiapatito ; Cirugía ; Técnica ; Puerco miniatura ; Microscopía fluorescencia ; Exploración ; Artiodactyla ; Ungulata ; Mammalia ; Vertebrata ; Estomatología ;

Localisation / Location

INIST-CNRS, Cote INIST : 3005, 35400005982351.0090