Titre du document / Document title

Dietary polyunsaturated fatty acids and composition of human aortic plaques

Auteur(s) / Author(s)

FELTON C. V. ⁽¹⁾ ; CROOK D. ⁽¹⁾ ; DAVIES M. J. ; OLIVER M. F. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Wynn inst. metabolic res., London NW8 9SQ, ROYAUME-UNI

Résumé / Abstract

How long-term dietary intake of essential fatty acids affects the fatty-acid content of aortic plaques is not clear. We compared the fatty-acid composition of aortic plaques with that of post-mortem serum and adipose tissue, in which essential fatty-acid content reflects dietary intake. Positive associations were found between serum and plaque ω6 (r=0.75) and ω3 (r=0.93) polyunsaturated fatty acids, and monounsaturates (r=0.70), and also between adipose tissue and plaque ω6 polyunsaturated fatty acids (r=0.89). No associations were found with saturated fatty acids. These findings imply a direct influence of dietary polyunsaturated fatty acids on aortic plaque formation and suggest that current trends favouring increased intake of polyunsaturated fatty acids should be reconsidered

Revue / Journal Title

Lancet   ISSN 0140-6736   CODEN LANCAO 

Source / Source

1994, vol. 344, n^o8931, pp. 1195-1196 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lancet, London, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Dietetics ; Polyunsaturated fatty acid ; Atherosclerosis ; Aorta ; Pathogenesis ; Human ; Aortic disease ; Cardiovascular disease ;

Mots-clés français / French Keywords

Diététique ; Acide gras polyinsaturé ; Athérosclérose ; Aorte ; Pathogénie ; Homme ; Aorte pathologie ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Dietetica ; Acido graso poliinsaturado ; Ateroesclerosis ; Aorta ; Patogenia ; Hombre ; Aorta patología ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400004216140.0080