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Titre du document / Document title

Dietary polyunsaturated fatty acids and composition of human aortic plaques

Auteur(s) / Author(s)

FELTON C. V. (1) ; CROOK D. (1) ; DAVIES M. J. ; OLIVER M. F. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Wynn inst. metabolic res., London NW8 9SQ, ROYAUME-UNI

Résumé / Abstract

How long-term dietary intake of essential fatty acids affects the fatty-acid content of aortic plaques is not clear. We compared the fatty-acid composition of aortic plaques with that of post-mortem serum and adipose tissue, in which essential fatty-acid content reflects dietary intake. Positive associations were found between serum and plaque ω6 (r=0.75) and ω3 (r=0.93) polyunsaturated fatty acids, and monounsaturates (r=0.70), and also between adipose tissue and plaque ω6 polyunsaturated fatty acids (r=0.89). No associations were found with saturated fatty acids. These findings imply a direct influence of dietary polyunsaturated fatty acids on aortic plaque formation and suggest that current trends favouring increased intake of polyunsaturated fatty acids should be reconsidered

Revue / Journal Title

Lancet    ISSN  0140-6736   CODEN LANCAO 

Source / Source

1994, vol. 344, no8931, pp. 1195-1196 (9 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1823) (Revue)

Mots-clés anglais / English Keywords

Dietetics

;

Polyunsaturated fatty acid

;

Atherosclerosis

;

Aorta

;

Pathogenesis

;

Human

;

Aortic disease

;

Cardiovascular disease

;

Mots-clés français / French Keywords

Diététique

;

Acide gras polyinsaturé

;

Athérosclérose

;

Aorte

;

Pathogénie

;

Homme

;

Aorte pathologie

;

Appareil circulatoire pathologie

;

Mots-clés espagnols / Spanish Keywords

Dietetica

;

Acido graso poliinsaturado

;

Ateroesclerosis

;

Aorta

;

Patogenia

;

Hombre

;

Aorta patología

;

Aparato circulatorio patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 5004, 35400004216140.0080

Nº notice refdoc (ud4) : 3317539



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