Titre du document / Document title

Schlafapnoe als Risikomarker bei koronarer Herzkrankheit = Sleep apnea as a risk marker in coronary heart disease

Auteur(s) / Author(s)

SCHÄFER H. ⁽¹⁾ ; EWIG S. ⁽¹⁾ ; HASPER E. ⁽¹⁾ ; KOEHLER U. ⁽²⁾ ; OEHM S. ⁽¹⁾ ; PIZZULLI L. ⁽¹⁾ ; LÜDERITZ B. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Medizinische Universitätsklinik und Poliklinik Bonn, Sigmund-Freud-Strasse 25, 53105 Bonn, ALLEMAGNE
⁽²⁾ Medizinische Poliklinik, Zentrum Innere Medizin, der Universität Marburg, Baldingerstrasse 1, 35033 Marburg, ALLEMAGNE

Résumé / Abstract

Obstructive sleep apnea (OSA) and coronary heart disease (CHD) are both frequent in the middle ages. Both diseases share a similar spectrum of risk factors and attendant diseases. The aim of the study was to determine the prevalence of obstructive sleep apnea in patients with coronary heart disease diagnosed by coronary angiography. Furthermore, influence of sleep apnea and attendant diseases and risk factors for coronary heart disease, especially the risk for myocardial infarction and reduced left ventricular ejection fraction, was investigated. We included in this study 143 patients (121 men, 22 women, mean age 60 ± 8 years (35-81) who underwent coronary angiography because of angina pectoris or were suspicious for CHD due to noninvasive investigations. These patients had symptoms of OSA based on a standardized questionnaire. They underwent a four-channel screening with a non-laboratory-monitoring-system (NLMS) for detection of sleep-related breathing disorders. In addition, spectrum of risk factors and concomitant diseases were considered. Sleep apnea was more frequent in patients with CHD (30.6 %) in comparison to patients without CHD (21.8 %), but did not reach statistical significance. Patients with CHD and OSA had a significantly higher frequency of a history of myocardial infarction and had a significantly lower left ventricular ejection fraction than patients without OSA. In conclusion: Patients with the combination of OSA and CHD are at higher risk for myocardial infarction and reduced left ventricular ejection fraction. Patients with CHD should be screened for OSA in case of secondary prevention.

Revue / Journal Title

Zeitschrift für Kardiologie   ISSN 0300-5860   CODEN ZKRDAX 

Source / Source

1996, vol. 85, n^o10, pp. 768-775 (27 ref.)

Langue / Language

Allemand
Revue : Anglais

Editeur / Publisher

Steinkopff, Darmstadt, ALLEMAGNE  (1973-2005) (Revue)

Mots-clés anglais / English Keywords

Coronary heart disease ; Sleep apnea syndrome ; Risk factor ; Human ; Cardiovascular disease ;

Mots-clés français / French Keywords

Cardiopathie coronaire ; Apnée sommeil syndrome ; Facteur risque ; Homme ; Appareil circulatoire pathologie ;

Mots-clés espagnols / Spanish Keywords

Cardiopatía coronaria ; Apnea sueno síndrome ; Factor riesgo ; Hombre ; Aparato circulatorio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 8594, 35400006674890.0050