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Titre du document / Document title

Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography

Auteur(s) / Author(s)

RAUHA J.-P. (1) ; SOLOMIES H. (1) ; AALTO M. (2) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacy, Pharmaceutical Chemistry Division, P.O. Box 56 (Viikinkaari 5), University of Helsinki, 00014 Helsinki, FINLANDE
(2) Association of Finnish Pharmacies, Pieni Roobertinkatu 14C, 00120 Helsinki, FINLANDE

Résumé / Abstract

Liquid chromatographic methods were developed for the determination of bromhexine hydrochloride. methyl p-hydroxybenzoate and propyl p-hydroxybenzoate (method A) and dextromethorphan hydrobromide (method B) in cough-cold syrup formulations. Reversed-phase analytical columns (150 mm x 3.9 mm i.d.) were used with (A) C18 and (B) phenyl as stationary phases and mixtures of (A) acetonitrile and aqueous 15 mM triethylamine solution (43 :57) and (B) methanol and aqueous 3% ammonium formate buffer solution (53 :47) as mobile phases at a flow rate of 1.0 ml min-1. Both aqueous components were adjusted to pH 3.9. UV detection of analytes was at (A) 245 nm and (B) 278 nm. In both methods, the time required for an HPLC run giving good separations and recoveries was less than 8 min.

Revue / Journal Title

Journal of pharmaceutical and biomedical analysis    ISSN  0731-7085   CODEN JPBADA 

Source / Source

1996, vol. 15, no2, pp. 287-293 (11 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1983) (Revue)

Mots-clés anglais / English Keywords

Dosage form

;

Quantitative analysis

;

Syrup

;

Antitussive agent

;

Concurrent

;

HPLC chromatography

;

Mots-clés français / French Keywords

Bromhexine

;

Dextrométhorphane

;

Forme pharmaceutique

;

Analyse quantitative

;

Sirop

;

Antitussif

;

Simultané

;

Chromatographie HPLC

;

Benzoïque acide(4-hydroxy) dérivé

;

Mots-clés espagnols / Spanish Keywords

Forma farmacéutica

;

Análisis cuantitativo

;

Jarabe

;

Antitusivo

;

Simultáneo

;

Cromatografía HPLC

;

Localisation / Location

INIST-CNRS, Cote INIST : 19962, 35400006683313.0160

Nº notice refdoc (ud4) : 3252929



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