Titre du document / Document title

Proneness to formation of tight and rigid fibrin gel structures in men with myocardial infarction at a young age

Auteur(s) / Author(s)

FATAH K. ⁽¹⁾ ; SILVEIRA A. ⁽²⁾ ; TORNVALL P. ^{(2 3)} ; KARPE F. ^{(2 4)} ; BLOMBÄCK M. ⁽¹⁾ ; HAMSTEN A. ^{(2 4)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Laboratory Medicine/Coagulation Research, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, SUEDE
⁽²⁾ Atherosclerosis Research Unit, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, SUEDE
⁽³⁾ Division of Cardiology, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, SUEDE
⁽⁴⁾ Division of Internal Medicine, King Gustaf V Research Institute, Department of Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, SUEDE

Résumé / Abstract

The native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of hydrated fibrin gel networks in 38 unselected men who had suffered a myocardial infarction before the age of 45 years and in 88 age-matched population-based control men. Both the fibrin gel porosity (permeability coefficient, Ks) and the calculated fiber mass-length ratio varied considerably within the two groups, but were generally lower in the patients. Ks was 8.3 ± 5.2 cm² x 10⁹ (mean ± SD) in the patient group and 12.5 ± 5.7 cm² x 10⁹ among controls (p <0.001). The corresponding figures for fiber mass-length ratio were 13.1 ± 7.7 and 16.5 ± 7.5 Dalton/cm x 10^-13, respectively (p <0.01). Around 50% of the patients had Ks values below the 10th percentile of the control group. A strong inverse correlation was seen between plasma plasminogen activator inhibitor-1 (PAI-I) activity and Ks (r = -0.603, p <0.001) or fiber mass-length ratio (r = -0.565, p <0.001) in the patient group. Corresponding weaker associations of PAI-I with fibrin gel properties were also present in the control group. In addition, inverse relationships of very low density lipoprotein (VLDL) triglyceride concentrations to Ks (r = -0.362, p <0.001) and fiber mass-length ratio (r = -0.283, p <0.01) were found among the controls. Proneness to formation of tight and rigid fibrin gel networks with abnormal architecture in vitro is in vivo associated with myocardial infarction at a young age. Impaired fibrinolytic function secondary to a raised plasma PAI-I activity level is associated with abnormal fibrin gel structure.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

1996, vol. 76, n^o4, pp. 535-540 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Infarct ; Myocardium ; Fibrin ; Colloidal gel ; Structure ; In vitro ; Fibrinolysis ; Cholesterol LDL ; Lipoprotein VLDL ; Young adult ; Plasminogen activator inhibitor 1 ; Human ; Cardiovascular disease ; Coronary heart disease ; Myocardial disease ;

Mots-clés français / French Keywords

Infarctus ; Myocarde ; Fibrine ; Gel colloïdal ; Structure ; In vitro ; Fibrinolyse ; Cholestérol LDL ; Lipoprotéine VLDL ; Adulte jeune ; Inhibiteur plasminogen activator 1 ; Homme ; Appareil circulatoire pathologie ; Cardiopathie coronaire ; Myocarde pathologie ;

Mots-clés espagnols / Spanish Keywords

Infarto ; Miocardio ; Fibrina ; Gel coloidal ; Estructura ; In vitro ; Fibrinólisis ; Colesterol LDL ; Lipoproteína VLDL ; Adulto joven ; Hombre ; Aparato circulatorio patología ; Cardiopatía coronaria ; Miocardio patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400006648910.0110