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Titre du document / Document title

Comparative evaluation of efficacy and safety of ciprofloxacin and norfloxacin ophthalmic solutions

Auteur(s) / Author(s)

ADENIS J. P. (1) ; BRASSEUR G. (2) ; DEMAILLY P. (3) ; MALET F. (4) ; VERIN P. (5) ; SAINT-BLANCAT P. (1) ; RETOUT A. (2) ; OLLE P. (2) ; COLIN J. (4) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) CHU Dupuytren, Limoges, FRANCE
(2) Charles Nicolle Hospital, Rouen, FRANCE
(3) Saint-Joseph Hospital, Ophthalmology Service, Paris, FRANCE
(4) CHRU Morvan, Brest, FRANCE
(5) Centre Jean Abadie, Ophthalmology Service, Bordeaux, FRANCE

Résumé / Abstract

The efficacy and safety of ciprofloxacin ophthalmic solution 0.3% and norfloxacin ophthalmic solution 0.3% in the treatment of bacterial conjunctivitis and blepharitis were compared in a double masked randomised study. A total of 131 patients, 65 treated with ciprofloxacin (42 with conjunctivitis and 23 with blepharitis) and 66 treated with norfloxacin (39 with conjunctivitis and 27 with blepharitis) were enrolled in the study at five centres in France. In the efficacy population, pathogens were eradicated or reduced in 96% (24/25) of patients in the ciprofloxacin group and 89% (24/27) in the norfloxacin group. There was no difference between treatments with regard to eradication of particular pathogens. In the efficacy population, clinical cure or improvement was seen in 96% of the patients (24/25 in the ciprofloxacin group and 26/27 in the norfloxacin group). There were no significant differences between ciprofloxacin and norfloxacin with respect to improvements in four symptoms or ten clinical signs. No serious treatment-related adverse events were reported and both ciprofloxacin and norfloxacin were well tolerated.

Revue / Journal Title

European journal of ophthalmology    ISSN  1120-6721 

Source / Source

1996, vol. 6, no3, pp. 287-292 (26 ref.)

Langue / Language

Anglais

Editeur / Publisher

Wichtig, Milano, ITALIE  (1991) (Revue)

Mots-clés anglais / English Keywords

Conjunctivitis

;

Bacteriosis

;

Blepharitis

;

Chemotherapy

;

Treatment

;

Antibiotic

;

Eye drop

;

Treatment efficiency

;

Human

;

Comparative study

;

Fluoroquinolone derivative

;

Quinolone derivative

;

Infection

;

Eye disease

;

Conjunctiva disease

;

Eyelid disease

;

Mots-clés français / French Keywords

Conjonctivite

;

Bactériose

;

Blépharite

;

Chimiothérapie

;

Traitement

;

Ciprofloxacine

;

Antibiotique

;

Norfloxacine

;

Collyre

;

Efficacité traitement

;

Homme

;

Etude comparative

;

Fluoroquinolone dérivé

;

Quinolone dérivé

;

Infection

;

Oeil pathologie

;

Conjonctive pathologie

;

Paupière pathologie

;

Mots-clés espagnols / Spanish Keywords

Conjuntivitis

;

Bacteriosis

;

Blefaritis

;

Quimioterapia

;

Tratamiento

;

Antibiótico

;

Colirio

;

Eficacia tratamiento

;

Hombre

;

Estudio comparativo

;

Fluoroquinolone derivado

;

Quinolone derivado

;

Infección

;

Ojo patología

;

Conjuntiva patología

;

Párpado patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 22516, 35400006636014.0120

Nº notice refdoc (ud4) : 3229105



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