Titre du document / Document title
Development of bioactive functions in hydrangae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (−)-hydrangenol 4'-O-glucoside, and (+)-hydrangenol 4'-O-glucoside
Auteur(s) / Author(s)
YOSHIKAWA M. (1) ;
MATSUDA H. (1) ;
SHIMODA H. (1) ;
SHIMADA H. (1) ;
HARADA E. (1) ;
NAITOH Y. (1) ;
MIKI A. (1) ;
YAMAHARA J. (1) ;
MURAKAMI N. (2) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, JAPON
(2) Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607, JAPON
Résumé / Abstract
Following the characterization of thunberginols A, B, and F, six bioactive principles, thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-O-glucoside, and (+)-hydrangenol 4'-O-glucoside, were isolated from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with four kaempferol and quercetin oligoglycosides. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. Thunberginols C, D, E, and G and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schultz-Dale reaction. These components also exhibited inhibitory activities on the histamine release from rat mast cells and on the histamine-induced contraction in isolated guinea pig tracheal chain. In addition, thunberginols C, D, E, and G showed antimicrobial activities against oral bacteria.
Revue / Journal Title
Chemical and pharmaceutical bulletin
ISSN
0009-2363
CODEN CPBTAL
Source / Source
1996, vol. 44, n
o8, pp. 1440-1447 (16 ref.)
Langue / Language
Anglais
Editeur / Publisher
JAACC, Tokyo, JAPON
(1958)
(Revue)
Mots-clés anglais / English Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Mots-clés français / French Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Mots-clés espagnols / Spanish Keywords
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
;
Localisation / Location
INIST-CNRS, Cote INIST : 4123, 35400006639315.0040
Nº notice refdoc (ud4) : 3226693
