Titre du document / Document title

The female brain hypoestrogenic continuum from the premenstrual syndrome to menopause : A hypothesis and review of supporting data

Auteur(s) / Author(s)

ARPELS J. C. ^{(1 2)} ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics, Gynecology and Reproductive Medicine, University of California, San Francisco, California, ETATS-UNIS
⁽²⁾ California Pacific Medical Center, San Francisco, California, ETATS-UNIS

Résumé / Abstract

OBJECTIVE : To propose a theory to help unify the symptoms of premenstrual syndrome (PMS), postpartum blues and depression, the perimenopausal transition and menopause. STUDY DESIGN : A review of supporting data is used to explain the possible neuroendocrine mechanism upon which the hypothesis is based. CONCLUSION : The brain in women has been shown to be an estrogen target organ. Common symptoms are shared by women complaining of PMS, postpartum blues, the perimenopausal transition and menopause : depression, sleep disturbance, irritability, anxiety and panic, memory and cognitive dysfunction and a decreased sense of well-being. The antiestrogens progesterone, progestin and tamox-ifen may also elicit these same symptoms. It is proposed that whenever brain estrogen levels fall below the minimum brain estrogen requirement, for whatever reason and at whatever age, brain center dysfunction may ensue.

Revue / Journal Title

Journal of reproductive medicine   ISSN 0024-7758   CODEN JRPMAP 

Source / Source

1996, vol. 41, n^o9, pp. 633-639 (87 ref.)

Langue / Language

Anglais

Editeur / Publisher

Science, Saint-Louis, MO, ETATS-UNIS  (1969) (Revue)

Mots-clés anglais / English Keywords

Premenstrual syndrome ; Hypoestrogenosis ; Brain (vertebrata) ; Progesterone ; Estrogen ; Menopause ; Depression ; Puerperium ; Human ; Female ; Female genital diseases ; Menstruation disorders ; Ovarian hormone ; Sex steroid hormone ; Progestagen ; Puerperal disorders ; Psychopathology ;

Mots-clés français / French Keywords

Prémenstruel syndrome ; Hypooestrogénie ; Encéphale ; Progestérone ; Oestrogène ; Ménopause ; Etat dépressif ; Postpartum ; Homme ; Femelle ; Appareil génital femelle pathologie ; Cycle menstruel pathologie ; Hormone ovarienne ; Hormone stéroïde sexuelle ; Progestatif ; Postpartum pathologie ; Psychopathologie ;

Mots-clés espagnols / Spanish Keywords

Premenstrual síndrome ; Hipoestrogenismo ; Encéfalo ; Progesterona ; Estrógeno ; Menopausia ; Estado depresivo ; Postparto ; Hombre ; Hembra ; Aparato genital hembra patología ; Ciclo menstrual patología ; Hormona ovárica ; Hormona esteroide sexual ; Progestágeno ; Postparto patología ; Psicopatología ;

Localisation / Location

INIST-CNRS, Cote INIST : 17097, 35400006622790.0030