Titre du document / Document title

Efficacy of buspirone in alcohol dependence : A review

Auteur(s) / Author(s)

MALEC T. S. ; MALEC E. A. ; DONGIER M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Douglas Hospital Research Center, Alcohol Research Program, Montral, Quebec, CANADA
McGill University, Montreal, Quebec, CANADA

Résumé / Abstract

The five published controlled studies on the effects of buspirone in alcoholism treatment are reviewed. They have been conducted mostly in alcoholics with comorbid anxiety. Significant differences in favor of the medication were observed in several psychopathological measures (anxiety, depression, hostility, interpersonal sensitivity, and global psychopathology). In only two studies were alcohol craving and consumption found influenced. Metaanalysis showed positive effects of buspirone on treatment retention, as well as on anxiety. R can be concluded that the main effect of buspirone in the treatment of alcoholism is not on ethanol consumption per se, but on associated psychopathological symptoms. A favorable safety profile and a lack of Interaction with alcohol make buspirone a useful pharmacological adjunct in the treatment of alcoholism.

Revue / Journal Title

Alcoholism, clinical and experimental research   ISSN 0145-6008   CODEN ACRSDM 

Source / Source

1996, vol. 20, n^o5, pp. 853-858 (39 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Baltimore, MD, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Alcoholism ; Chemotherapy ; Treatment ; Tranquillizer ; Psychotropic ; Antialcohol drug ; Anxiety ; Depression ; Mood disorder ; Concomitant disease ; Metaanalysis ; Human ;

Mots-clés français / French Keywords

Alcoolisme ; Chimiothérapie ; Traitement ; Buspirone ; Tranquillisant ; Psychotrope ; Antialcoolique ; Angoisse anxiété ; Etat dépressif ; Trouble humeur ; Association morbide ; Métaanalyse ; Homme ;

Mots-clés espagnols / Spanish Keywords

Alcoholismo ; Quimioterapia ; Tratamiento ; Tranquilizante ; Psicotropo ; Antialcohólico ; Angustia ansiedad ; Estado depresivo ; Trastorno humor ; Asociación morbosa ; Mataanálisis ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 17114, 35400006410402.0110