Titre du document / Document title

Characterising drug release processes within controlled release dosage forms using the confocal laser scanning microscope

Auteur(s) / Author(s)

CUTTS L. S. ⁽¹⁾ ; HIBBERD S. ⁽²⁾ ; ADLER J. ⁽¹⁾ ; DAVIES M. C. ⁽¹⁾ ; MELIA C. D. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, ROYAUME-UNI
⁽²⁾ Department of Theoretical Mechanics, University of Nottingham, University Park, Nottingham, NG7 2RD, ROYAUME-UNI

Résumé / Abstract

A new method has been developed for quantifying drug release processes within controlled release dosage forms using the confocal laser scanning microscope (CLSM). The changing internal distribution of a fluorescent marker drug (minocycline HCI) within a spherical controlled release pellet undergoing drug release was followed using CLSM, which allowed internal mapping of the drug non-invasively and without prior sample preparation. Image analysis routines were developed to quantify the changing drug concentration profile with time across the radius of the pellet, and the results were fitted to a theoretically derived mathematical model which predicted a biphasic depletion mechanism. The experimental results closely fitted the predicted profile, and enabled calculation of the drug dissolution rate constant, the diffusion coefficient of drug within the matrix, and the time drug dissolution within the matrix ended.

Revue / Journal Title

Journal of controlled release   ISSN 0168-3659   CODEN JCREEC 

Source / Source

1996, vol. 42, n^o2, pp. 115-124 (13 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1984) (Revue)

Mots-clés anglais / English Keywords

Drug ; Release ; Active ingredient ; Controlled release form ; Dosage form ; Investigation method ; Pharmaceutical technology ; Confocal microscopy ; Scanning microscope ; Laser beam ; Mathematical model ;

Mots-clés français / French Keywords

Médicament ; Libération ; Principe actif ; Forme libération contrôlée ; Forme pharmaceutique ; Méthode étude ; Technologie pharmaceutique ; Microscopie confocale ; Microscope balayage ; Faisceau laser ; Modèle mathématique ;

Mots-clés espagnols / Spanish Keywords

Medicamento ; Liberación ; Principio activo ; Forma liberación controlada ; Forma farmacéutica ; Método estudio ; Tecnología farmacéutica ; Microscopía confocal ; Microscopio barrido ; Haz láser ; Modelo matemático ;

Localisation / Location

INIST-CNRS, Cote INIST : 20704, 35400006620646.0020