Titre du document / Document title

Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats

Auteur(s) / Author(s)

SHIMABUKURO M. ⁽¹⁾ ; HIGA S. ⁽¹⁾ ; SHINZATO T. ⁽¹⁾ ; NAGAMINE F. ⁽¹⁾ ; KOMIYA I. ⁽¹⁾ ; TAKASU N. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Second Department of Internal Medicine, Faculty of Medicine, University of The Ryukus, Okinawa, JAPON

Résumé / Abstract

Troglitazone, a new oral antidiabetic agent, shows hypoglycemic effects in insulin-resistant animal models and humans. This study was conducted to evaluate the effects of troglitazone on the heart of diabetic animals. Streptozotocin (STZ)-induced diabetic rats and age-matched controls were treated with troglitazone as a 0.2% food admixture for 6 weeks. Basal and postischemic cardiac functions at 14 weeks of age were then examined in isolated working heart. Troglitazone treatment did not attenuate the insulinopenia and hyperglycemia of diabetic rats, but it partially improved the hypertriglyceridemia. Troglitazone treatment partially restored the basal heart rate and cardiac work of diabetic rats to nearly control values. Troglitazone also improved the postischemic functional deficits of diabetic rats : heart rate (untreated 61% of baseline at 30-minute reperfusion v treated 92%, P <.001), left ventricular (LV) developed pressure (54% v 94%, P <.001), peak positive ([LV +dP/dt] 54% v 93%, P <.001) and negative ([LV -dP/dt] 53% v 94%, P <.001) first derivative of LV, and cardiac work (44% v 98%, P <.001). Diabetic animals showed ultrastructural damage including disarray of sarcomere, disorganization of mitochondrial matrix, cytoplasmic vacuolization, and invagination of nuclear membrane ; these were partially normalized by troglitazone treatment. Our results suggest that troglitazone treatment has a cardioprotective effect on the basal and postischemic cardiac function of STZ-induced diabetic rats.

Revue / Journal Title

Metabolism, clinical and experimental   ISSN 0026-0495 

Source / Source

1996, vol. 45, n^o9, pp. 1168-1173 (34 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1952) (Revue)

Mots-clés anglais / English Keywords

Diabetes mellitus ; Complication ; Heart disease ; Ischemia ; Myocardium ; Biological properties ; Chemotherapy ; Animal model ; Animal ; Rat ; Rodentia ; Mammalia ; Vertebrata ; Endocrinopathy ; Cardiovascular disease ; Hypoglycemic agent ;

Mots-clés français / French Keywords

Diabète ; Complication ; Cardiopathie ; Ischémie ; Myocarde ; Troglitazone ; Propriété biologique ; Chimiothérapie ; Modèle animal ; Animal ; Rat ; Rodentia ; Mammalia ; Vertebrata ; Endocrinopathie ; Appareil circulatoire pathologie ; Hypoglycémiant ;

Mots-clés espagnols / Spanish Keywords

Diabetes ; Complicación ; Cardiopatía ; Isquemia ; Miocardio ; Propiedad biológica ; Quimioterapia ; Modelo animal ; Animal ; Rata ; Rodentia ; Mammalia ; Vertebrata ; Endocrinopatía ; Aparato circulatorio patología ; Hipoglicemiante ;

Localisation / Location

INIST-CNRS, Cote INIST : 6965, 35400006577762.0190