Titre du document / Document title

Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population : The Rotterdam study

Auteur(s) / Author(s)

DIELEMANS I. ^{(1 2)} ; DE JONG P. T. V. M. ^{(2 3 4)} ; STOLK R. ⁽²⁾ ; VINGERLING J. R. ^{(1 2)} ; GROBBEE D. E. ⁽²⁾ ; HOFMAN A. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Ophthalmology, Erasmus University Medical School, Rotterdam, PAYS-BAS
⁽²⁾ Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, PAYS-BAS
⁽³⁾ The Netherlands Ophthalmic Research Institute, Amsterdam, PAYS-BAS
⁽⁴⁾ Department of Ophthalmology, Academic Medical Center, Amsterdam, PAYS-BAS

Résumé / Abstract

Purpose : To investigate the association of primary open-angle glaucoma and intraocular pressure (IOP) with newly diagnosed diabetes mellitus. Methods : Subjects participating in the Rotterdam Study (n = 4178 ; ages, 55 years and older) were examined according to standard protocols, including a medical history interview, perimetry, applanation tonometry, funduscopy, and a nonfasting glucose tolerance test. Glaucoma was defined by the presence of a glaucomatous visual field defect. A distinction was made between high-tension glaucoma and normal-tension glaucoma. The relation of glaucoma and IOP with newly diagnosed diabetes mellitus and blood glucose was analyzed using regression analysis. Results : The presence of diabetes mellitus was associated with an overall rise in mean IOP of both eyes of 0.31 mmHg (95% confidence interval, 0.12-0.50), and with a threefold increased presence of high-tension glaucoma (odds ratio, 3.11 ; 95% confidence interval, 1.12-8.66). A 10-mmol/l higher random serum glucose level was borderline significantly associated with a mean IOP that was, on average, 0.41 mmHg (95% confidence interval, -0.02-0.84) higher and with an odds ratio of 2.82 (95% confidence interval, 0.92-8.58) for high-tension glaucoma. A 10-mmol/l rise in serum glucose on a glucose tolerance test was associated with an overall rise of mean IOP of 0.59 mmHg (95% confidence interval, 0.26-0.92) and with an odds ratio of 1.88 (95% confidence interval, 0.81-4.32) for high-tension glaucoma. Conclusion : Newly diagnosed diabetes mellitus and high levels of blood glucose are associated with elevated IOP and high-tension glaucoma.

Revue / Journal Title

Ophthalmology   ISSN 0161-6420   CODEN OPHTDG 

Source / Source

1996, vol. 103, n^o8, pp. 1271-1275 (18 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1976) (Revue)

Mots-clés anglais / English Keywords

Open angle glaucoma ; Diabetes mellitus ; Intraocular pressure ; Association ; Elderly ; Human ; Eye disease ; Endocrinopathy ;

Mots-clés français / French Keywords

Glaucome angle ouvert ; Diabète ; Tonus oculaire ; Association ; Vieillard ; Homme ; Oeil pathologie ; Endocrinopathie ;

Mots-clés espagnols / Spanish Keywords

Glaucoma ángulo abierto ; Diabetes ; Tono ocular ; Asociación ; Anciano ; Hombre ; Ojo patología ; Endocrinopatía ;

Localisation / Location

INIST-CNRS, Cote INIST : 18914, 35400006409826.0190