Titre du document / Document title

Pineal response after pyridoxine test in children

Auteur(s) / Author(s)

MUNOZ-HOYOS A. ⁽¹⁾ ; AMOROS-RODRIGUEZ I. ⁽¹⁾ ; MOLINA-CARBALLO A. ⁽¹⁾ ; UBEROS-FERNANDEZ J. ⁽¹⁾ ; ACUNA-CASTROVIEJO D. ⁽²⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Departamento de Pediatría, Hospital Universitario, Facultad de Medicina, ESPAGNE
⁽²⁾ Instituto de Biotecnología, Universidad de Granada, ESPAGNE

Résumé / Abstract

To characterize the pineal response to pyridoxine, plasma melatonin was measured in one hundred and twenty children 3 hours after vitamin B₆ administration. The children, aged between 1.5 and 8 years, were divided in four groups as follows : a) control day group, grouping 27 children sampled at 9 :00 and at 12 :00 ; b) control night group, grouping 29 children sampled at 21 :00 and at 24 :00 ; c) pyridoxine day group, grouping 30 children sampled at 9 :00, then intravenously (i.v.) injected with 3mg/kg of pyridoxine, and sampled at 12 :00 : and d) pyridoxine night group, grouping 34 children sampled at 21 :00, i.v. injected with 3mg/kg of pyridoxine, and sampled at 24 :00. Melatonin concentration was measured by radioimmuno assay. The data obtained showed a significant increase in melatonin levels after pyridoxine administration in the pyridoxine night group (39.87 ± 8.02 pg/ml basal vs 88.45 ± 9.21 pg/ml after pyridoxine, p < 0.001). The other groups did not showed significant differences in melatonin concentrations. Statistical analysis shows that the administration of pyridoxine during the nocturnal hours represents a stimulating factor to increase the pineal production of melatonin in children.

Revue / Journal Title

Journal of neural transmission   ISSN 0300-9564   CODEN JNTMAH 

Source / Source

1996, vol. 103, n^o7, pp. 833-842 (2 p.1/4)

Langue / Language

Anglais

Editeur / Publisher

Springer, Wien, AUTRICHE  (1972) (Revue)

Mots-clés anglais / English Keywords

Pineal body ; Pyridoxine ; Melatonine ; Circadian rhythm ; Child ; Endocrine gland ; Pineal hormone ; Biological rhythm ; Human ;

Mots-clés français / French Keywords

Epiphyse ; Pyridoxine ; Mélatonine ; Rythme circadien ; Enfant ; Glande endocrine ; Hormone épiphysaire ; Rythme biologique ; Homme ;

Mots-clés espagnols / Spanish Keywords

Epífisis ; Piridoxina ; Melatonina ; Ritmo circadiano ; Niño ; Glándula endocrina ; Hormona epifisaria ; Ritmo biológico ; Hombre ;

Localisation / Location

INIST-CNRS, Cote INIST : 7168, 35400006386545.0050