Titre du document / Document title

Orthostatic hypotension induced by sertraline withdrawal

Auteur(s) / Author(s)

AMSDEN G. W. ⁽¹⁾ ; GEORGIAN F. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Pharmacy Services and The Clinical Pharmacology Research Center, Bassett Healthcare, Worcester, Massachusetts, ETATS-UNIS

Résumé / Abstract

Sertraline is a member of the newest class of antidepressants, the selective serotonin reuptake inhibitors. Due to its inherent selectivity and its lack of action with norepinephrine, dopamine, monoamine oxidase, and cholinergic receptors, this drug is unlikely to have any cardiovascular activity. A patient receiving sertraline for depression developed dizziness and orthostatic hypotension on repeated attempts to discontinue the drug. All other organic factors were ruled out. The hypotension was proved to be secondary to sertraline by repeated rechallenges. After a variety of attempted treatments, the agent was discontinued successfully through an extended titration period. This report should guide clinicians in treating patients with a similar problem.

Revue / Journal Title

Pharmacotherapy   ISSN 0277-0008   CODEN PHPYDQ 

Source / Source

1996, vol. 16, n^o4, pp. 684-686 (5 ref.)

Langue / Language

Anglais

Editeur / Publisher

Pharmacotherapy, Boston, MA, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Reuptake inhibitor ; Serotonin ; Withdrawal ; Toxicity ; Postural hypotension ; Withdrawal syndrome ; Human ; Antidepressant agent ; Psychotropic ; Cardiovascular disease ; Nervous system diseases ; Diseases of the autonomic nervous system ;

Mots-clés français / French Keywords

Sertraline ; Inhibiteur recapture ; Sérotonine ; Arrêt traitement ; Toxicité ; Hypotension artérielle orthostatique ; Sevrage syndrome ; Homme ; Antidépresseur ; Psychotrope ; Appareil circulatoire pathologie ; Système nerveux pathologie ; Système nerveux autonome pathologie ;

Mots-clés espagnols / Spanish Keywords

Inhibidor recaptura ; Serotonina ; Paro tratamiento ; Toxicidad ; Hipotensión arterial ortostática ; Destete síndrome ; Hombre ; Antidepresor ; Psicotropo ; Aparato circulatorio patología ; Sistema nervioso patología ; Sistema nervioso autónomo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 19165, 35400006360797.0190