Titre du document / Document title

Coagulation factor V gene mutation associated with activated protein C resistance leading to recurrent thrombosis, leg ulcers, and lymphedema : successful treatment with intermittent compression

Auteur(s) / Author(s)

PEUS D. ⁽¹⁾ ; SCHMIEDEBERG S. V. ⁽¹⁾ ; PIER A. ⁽¹⁾ ; SCHARF R. E. ; WEHMEIER A. ; RUZICKA T. ⁽¹⁾ ; KRUTMANN J. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology, Heinrich-Heine-University, Düsseldorf, ALLEMAGNE

Résumé / Abstract

Activated protein C resistance is the most frequent cause of venous thrombosis. We describe a patient with extensive ulcerations and severe lymphedema of the legs after recurrent thrombosis. Laboratory tests revealed a pathologic activated protein C resistance and a reduced functional protein S. The underlying genetic defect was identified as a heterozygous coagulation factor V mutation. A combined therapeutic approach of intermittent compression, repeated debridements and systemic antibiotics resulted in marked improvement of both lymphedema and leg ulcers.

Revue / Journal Title

Journal of the American Academy of Dermatology   ISSN 0190-9622   CODEN JAADDB 

Source / Source

1996, vol. 35 (2), n^o2, pp. 306-309 (37 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Protein C (activated) ; Resistance ; Deep vein thrombosis ; Mutation ; Gene ; Factor V ; Treatment ; Compression ; Ulcer ; Leg ; Case study ; Human ; Serine endopeptidases ; Proteinases ; Hydrolases ; Enzyme ; Coagulopathy ; Cardiovascular disease ; Vascular disease ; Venous disease ;

Mots-clés français / French Keywords

Protein C (activated) ; Résistance ; Thrombose profonde ; Mutation ; Gène ; Proaccélérine ; Traitement ; Compression ; Ulcère ; Jambe ; Etude cas ; Homme ; Serine endopeptidases ; Proteinases ; Hydrolases ; Enzyme ; Coagulopathie ; Appareil circulatoire pathologie ; Vaisseau sanguin pathologie ; Veine pathologie ;

Mots-clés espagnols / Spanish Keywords

Protein C (activated) ; Resistencia ; Trombosis venosa profunda ; Mutación ; Gen ; Proacelerina ; Tratamiento ; Compresión ; Ulcera ; Pierna ; Estudio caso ; Hombre ; Serine endopeptidases ; Proteinases ; Hydrolases ; Enzima ; Coagulopatía ; Aparato circulatorio patología ; Vaso sanguíneo patología ; Vena patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 18387, 35400006373501.0070