Titre du document / Document title

Influence of metabolic control on thromboxane biosynthesis and plasma plasminogen activator inhibitor type-1 in non-insulin-dependent diabetes mellitus

Auteur(s) / Author(s)

DAVI G. ⁽¹⁾ ; BELVEDERE M. ; VIGNERI S. ; CATALANO I. ; GIAMMARRESI C. ; ROCCAFORTE S. ⁽¹⁾ ; CONSOLI A. ⁽¹⁾ ; MEZZETTI A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Internal Medicine, University of Chieti, ITALIE

Résumé / Abstract

We have previously shown that tight metabolic control by insulin therapy reduced thromboxane-dependent platelet activation in non-insulin-dependent diabetes mellitus (NIDDM) patients. The present study was undertaken to determine whether a similar effect could be obtained without switching diabetics in secondary failure to insulin treatment. For this purpose, we gave strict diet and exercise advise program and adjusted on a weekly basis the oral antidiabetic therapy (glipizide) that 26 patients with NIDDM had been given over the previous months. Basal measurements of urinary 11-dehydro-TXB₂ and PAT-1 confirmed previous findings of enhanced levels of these parameters in NIDDM patients with macrovascular disease in comparison to age-and sex-matched controls. After 2-6 weeks, 16 patients achieved tight metabolic control associated with significant reduction of both thromboxane biosynthesis and PAI-I levels ; 10 patients remained in poor control and no significant decrease of both parameters was observed. We conclude that reduction of in-vivo platelet activation and PAI-1 antigen levels after metabolic improvement obtained by frequent reassessment of sulphonylurea therapy together with strict diet and exercise programs may have beneficial effects on the progression of diabetic micro- and macrovascular disease.

Revue / Journal Title

Thrombosis and haemostasis   ISSN 0340-6245   CODEN THHADQ 

Source / Source

1996, vol. 76, n^o1, pp. 34-37 (27 ref.)

Langue / Language

Anglais

Editeur / Publisher

Schattauer, Stuttgart, ALLEMAGNE  (1976) (Revue)

Mots-clés anglais / English Keywords

Non insulin dependent diabetes ; Thromboxane ; Biosynthesis ; Metabolism ; Regulation(control) ; Human ; Plasminogen activator inhibitor 1 ; Endocrinopathy ; Arachidonic acid derivatives ;

Mots-clés français / French Keywords

Diabète non insulinodépendant ; Thromboxane ; Biosynthèse ; Métabolisme ; Régulation ; Homme ; Inhibiteur plasminogen activator 1 ; Endocrinopathie ; Arachidonique acide dérivé ;

Mots-clés espagnols / Spanish Keywords

Diabetes no insulinodependiente ; Tromboxano ; Biosíntesis ; Metabolismo ; Regulación ; Hombre ; Endocrinopatía ; Araquidónico ácido derivado ;

Localisation / Location

INIST-CNRS, Cote INIST : 10255, 35400006051438.0080