Titre du document / Document title

Drug interactions with azithromycin and the macrolides : an overview

Auteur(s) / Author(s)

NAHATA M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Colleges of Pharmacy and Medicine Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, ETATS-UNIS

Résumé / Abstract

Evidence interactions between individual macrolides and a number of pharmacologically active compounds that are frequently co-administered to patients with bacterial infections is reviewed. Theophylline is strongly associated with erythromycin interaction ; clarithromycin may also interact with this drug. Azithromycin, spiramycin and rokitamycin, however, do not appear to have any effect on theophylline pharmacokinetics. The other therapeutic agents considered are cyclosporin, the antiepileptics, carbamazepine and phenytoin, terfenadine, warfarin, oral contraceptives, agents used in the management of gastritis and peptic ulcer and zidovudine. With the exception of interaction with antacids, there is no evidence that azithromycin, unlike most other macrolides, interacts with any of these agents to produce clinically significant adverse effects. The explanation for this variation appears to be azithromycin's inability to induce and bind to the cytochrome P450 IIIA enzyme system.

Revue / Journal Title

Journal of antimicrobial chemotherapy   ISSN 0305-7453   CODEN JACHDX 

Source / Source

1996, vol. 37, SUPC (167 p.)  (2 p.), pp. 133-142

Langue / Language

Anglais

Editeur / Publisher

Oxford University Press, Oxford, ROYAUME-UNI  (1975) (Revue)

Mots-clés anglais / English Keywords

Antibiotic ; Antibacterial agent ; Drug interaction ; Review ; Theophyllin ; Anticonvulsant ; Anticoagulant ; Contraceptive ; Oral administration ; Macrolide ; Xanthine derivatives ;

Mots-clés français / French Keywords

Azithromycine ; Antibiotique ; Antibactérien ; Interaction médicamenteuse ; Article synthèse ; Théophylline ; Ciclosporine ; Anticonvulsivant ; Terfénadine ; Anticoagulant ; Contraceptif ; Voie orale ; Zidovudine ; Macrolide ; Xanthine dérivé ;

Mots-clés espagnols / Spanish Keywords

Antibiótico ; Antibacteriano ; Interacción medicamentosa ; Artículo síntesis ; Anticonvulsivante ; Anticoagulante ; Anticonceptivo ; Vía oral ; Macrólido ; Xantina derivado ;

Localisation / Location

INIST-CNRS, Cote INIST : 17084, 35400006031356.0140