Titre du document / Document title

Correlation of fecundability and serum estradiol after danazol treatment in patients with advanced endometriosis

Auteur(s) / Author(s)

CHEN F.-P. ⁽¹⁾ ; CHU K.-K. ⁽¹⁾ ; SOONG Y.-K. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung, TAIWAN, PROVINCE DE CHINE

Résumé / Abstract

Objective : To examine the relationship between pregnancy incidence and the level of serum E₂ during danazol therapy. Design : Danazol was given by 200 mg four times daily for 3 months. Serum E₂ level was checked after completing the therapy, but before stopping medication. Patients then were advised to conceive at the appropriate time over a 6-month period. Setting : Reproductive and Endocrine Laboratory of the Department of Obstetrics and Gynecology, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. Patients : Infertile women with invasive endometriosis receiving conservative surgery and danazol treatment. Interventions : Serum E₂ is checked before medication and at the end of danazol therapy, but before stopping medication. Main Outcome Measures : Whether pregnancy is related to the change of serum E₂ caused by danazol therapy. Results : There were 24 pregnancies in 38 patients with invasive endometriosis after treatment. Pregnant patients had significantly lower serum E₂ levels as compared with the nonpregnant patients. Conclusions : After conservative surgery for invasive endometriosis associated with infertility, the therapeutic period of danazol treatment could be shortened to 3 months. Because there is significant correlation of fecundability and serum E₂ after danazol medication, serum E₂ could be a guideline for predicting pregnancy or for prolonging or changing of treatment after danazol therapy.

Revue / Journal Title

Fertility and sterility   ISSN 0015-0282   CODEN FESTAS 

Source / Source

Congrès
World Congress on In Vitro Fertilization and Alternate Assisted Reproduction N^o9, Vienna , AUTRICHE (03/04/1995)
1996, vol. 65, n^o6, pp. 1232-1234 (4 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier Science, New York, NY, ETATS-UNIS  (1950) (Revue)

Mots-clés anglais / English Keywords

17β-Estradiol ; Chemotherapy ; Treatment ; Prognosis ; Pregnancy ; Hormonal investigation ; Conservative surgery ; Endometriosis ; Danazol ; Androgen ; Antagonist ; Gonadotropin ; Endoscopic surgery ; Human ; Female ; Estrogen ; Ovarian hormone ; Female genital diseases ; Uterine diseases ;

Mots-clés français / French Keywords

17β-Oestradiol ; Chimiothérapie ; Traitement ; Pronostic ; Gestation ; Exploration hormonale ; Chirurgie conservatrice ; Endométriose ; Danazol ; Androgène ; Antagoniste ; Gonadotrophine ; Chirurgie endoscopique ; Homme ; Femelle ; Oestrogène ; Hormone ovarienne ; Appareil génital femelle pathologie ; Utérus pathologie ;

Mots-clés espagnols / Spanish Keywords

17β-Estradiol ; Quimioterapia ; Tratamiento ; Pronóstico ; Gestación ; Análisis hormonal ; Cirugía conservatriz ; Endometriosis ; Danazol ; Andrógeno ; Antagonista ; Gonadotropina ; Cirurgía endoscópica ; Hombre ; Hembra ; Estrógeno ; Hormona ovárica ; Aparato genital hembra patología ; Utero patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 4120, 35400004368412.0280