Titre du document / Document title
The effect of Simvastatin treatment on natural antioxidants in low-density lipproteins and high-energy phosphates and ubiquinone in skeletal muscle
Auteur(s) / Author(s)
LAAKSONEN R. ;
JAKELAINEN K. ;
LAAKSO J. ;
SAHI T. ;
HÄRKÖNEN M. ;
TIKKANEN M. J. ;
HIMBERG J.-J. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
Department of Clinical Pharmacology, University of Helsinki, FINLANDE
Résumé / Abstract
It has been hypothesized that treating hypercholesterolemic patients with statins will lead not only to a reduction in cholesterol, but also to inhibited synthesis of other compounds which derive from the synthetic pathway of cholesterol. In theory, this could further lead to ubiquinone deficiency in muscle cell mitochondria, disturbing normal cellular respiration and causing adverse effects such as rhabdomyolysis. Furthermore, ubiquinone is one of the lipophilic antioxidants in low-density lipoprotein (LDL), and therefore it has also been hypothesized that statin treatment will reduce the antioxidant capacity of LDL. We investigated the effect of 6 months of simvastatin treatment (20 mg/day) on skeletal muscle concentrations of high-energy phosphates and ubiquinone by performing biopsies in 19 hypercholesterolemic patients. Parallel assays were performed in untreated control subjects. The muscle high-energy phosphate and ubiquinone concentrations assayed after simvaslatin treatment were similar to those observed at baseline and did not differ from the values obtained in control subjects at the beginning and end of follow-up. These results do not support the hypothesis of diminished isoprenoid synthesis or energy generation in muscle cells during simvastatin treatment. Furthermore, the results of analysis of antioxidant concentrations in LDL before and after simvastafin treatment indicate that the antioxidant capacity of LDL is maintained in simvastatin-treated patients.
Revue / Journal Title
The American journal of cardiology
ISSN
0002-9149
CODEN AJCDAG
Source / Source
1996, vol. 77, n
o10, pp. 851-854 (25 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS
(1958)
(Revue)
Mots-clés anglais / English Keywords
Hypercholesterolemia ;
Enzyme inhibitor ;
Hydroxymethylglutaryl-CoA synthase ;
Antioxidant ;
Lipoprotein LDL ;
High energy phosphate ;
Ubiquinone ;
Striated muscle ;
Chemotherapy ;
Treatment ;
Exploration ;
Human ;
Lipids ;
Antilipemic agent ;
Oxo-acid-lyases ;
Carbon-carbon lyases ;
Lyases ;
Enzyme ;
Metabolic diseases ;
Hyperlipoproteinemia ;
Mots-clés français / French Keywords
Hypercholestérolémie ;
Simvastatine ;
Inhibiteur enzyme ;
Hydroxymethylglutaryl-CoA synthase ;
Antioxydant ;
Lipoprotéine LDL ;
Phosphate hautement énergétique ;
Ubiquinone ;
Muscle strié ;
Chimiothérapie ;
Traitement ;
Exploration ;
Homme ;
Lipide ;
Hypolipémiant ;
Oxo-acid-lyases ;
Carbon-carbon lyases ;
Lyases ;
Enzyme ;
Métabolisme pathologie ;
Hyperlipoprotéinémie ;
Mots-clés espagnols / Spanish Keywords
Hipercolesterolemia ;
Inhibidor enzima ;
Hydroxymethylglutaryl-CoA synthase ;
Antioxidante ;
Lipoproteína LDL ;
Fosfato altamente energético ;
Ubiquinona ;
Músculo estriado ;
Quimioterapia ;
Tratamiento ;
Exploración ;
Hombre ;
Lípido ;
Hipolipemiante ;
Oxo-acid-lyases ;
Carbon-carbon lyases ;
Lyases ;
Enzima ;
Metabolismo patología ;
Hiperlipoproteinemia ;
Localisation / Location
INIST-CNRS, Cote INIST : 8674, 35400004342862.0100
Nº notice refdoc (ud4) : 3100303
