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Titre du document / Document title

Pretrolatum is not comedogenic in rabbits or humans : A critical reappraisal of the rabbit ear assay and the concept of acne cosmetica

Auteur(s) / Author(s)

KLIGMAN A. M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, ETATS-UNIS

Résumé / Abstract

The objective was to find out whether petrolatum, previously reported to be comedogenic in the rabbit ear model, would worsen acne. Vaseline petrolatum jelly (Vaseline®, Chesebrough-Ponds) and Vaseline petrolatum jelly cream (Creamy Vaseline®, Chesebrough-Ponds) were applied to separate groups of ten acne patients each twice daily for eight weeks. No evidence of comedogenic potential was found by the follicular biopsy technique. Papulo-pustules significantly decreased in both groups. Greasiness cannot be equated with comedogenicity. The admonition for acne patients to seek oil-free skin care products has no scientific merit with regard ro comedogenicity. Cosmetics are an unlikely cause of the relatively high prevalence of post-adolescent female acne.

Revue / Journal Title

Journal of the Society of Cosmetic Chemists    ISSN  0037-9832   CODEN JSCCA5 

Source / Source

1996, vol. 47, no1, pp. 41-48 (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Society of Cosmetic Chemists, New York, NY, ETATS-UNIS  (1947-1997) (Revue)

Mots-clés anglais / English Keywords

Test method

;

Evaluation

;

Efficiency

;

Acne

;

Comedo

;

Dermatology

;

Raw materials

;

Petrolatum

;

Cosmetic

;

Formulation

;

Human

;

Skin disease

;

Mots-clés français / French Keywords

Méthode essai

;

Evaluation

;

Efficacité

;

Acné

;

Comédon

;

Dermatologie

;

Matière première

;

Petrolatum

;

Cosmétique

;

Formulation

;

Homme

;

Peau pathologie

;

Mots-clés espagnols / Spanish Keywords

Método ensayo

;

Evaluación

;

Eficacia

;

Acné

;

Comedón

;

Dermatología

;

Materia prima

;

Petrolato

;

Cosmético

;

Formulación

;

Hombre

;

Piel patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 6978, 35400004382330.0040

Nº notice refdoc (ud4) : 3097361



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