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Titre du document / Document title

Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus

Auteur(s) / Author(s)

MUROI H. (1) ; KUBO I. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Environmental Science, Policy and Management, University of California, Berkeley, CA, ETATS-UNIS

Résumé / Abstract

The inhibitory and bactericidal activities of anacardic acid and totarol, alone and in combination with methicillin, were investigated against methicillin-resistant Staphylococcus aureus (MRSA). The growth of two MRSA strains was inhibited by 6.25 μg ml-1 of anacardic acid and 0.78 μg ml-1 of totarol. The time-kill curve study showed that these two compounds were bactericidal against MRSA. Anacardic acid killed MRSA cells more rapidly than totarol, and no viable cells were detected after being exposed to 6.25 μg ml-1 of anacardic acid for 6 h. Anacardic acid showed bactericidal activity against MRSA at any stage of growth, and also even when cell division was inhibited by chloramphenicol. In the combination studies, the minimal inhibitory concentration (MIC) of methicillin was lowered from 800 to 1.56 μg ml-1 for MRSA ATCC 33591, and from 800 to 6.25 μg ml-1 for MRSA ATCC 33592, by combining with 1/2 x MIC of anacardic acid. The time-kill curves demonstrated synergistic bactericidal activities for these combinations.

Revue / Journal Title

Journal of applied bacteriology    ISSN  0021-8847   CODEN JABAA4 

Source / Source

1996, vol. 80, no4, pp. 387-394 (29 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1954-1996) (Revue)

Mots-clés anglais / English Keywords

Antibacterial agent

;

Plant origin

;

Medicinal plant

;

Pharmacognosy

;

Anacardium occidentale

;

Synergism

;

Penicillin derivatives

;

Bactericidal effect

;

Antibiotic

;

Minimum inhibitory concentration

;

Staphylococcus aureus

;

Anacardiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Micrococcaceae

;

Micrococcales

;

Bacteria

;

Mots-clés français / French Keywords

Anacardique acide

;

Antibactérien

;

Origine végétale

;

Plante médicinale

;

Pharmacognosie

;

Anacardium occidentale

;

Méticilline

;

Synergie

;

Pénicilline dérivé

;

Bactéricidie

;

Antibiotique

;

Concentration minimale inhibitrice

;

Staphylococcus aureus

;

Totarol

;

Podocarpus niger

;

Anacardiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Micrococcaceae

;

Micrococcales

;

Bactérie

;

Mots-clés espagnols / Spanish Keywords

Antibacteriano

;

Origen vegetal

;

Planta medicinal

;

Farmacognosia

;

Anacardium occidentale

;

Sinergia

;

Penicilinas

;

Bactericidia

;

Antibiótico

;

Concentración mínima inhibidora

;

Staphylococcus aureus

;

Anacardiaceae

;

Dicotyledones

;

Angiospermae

;

Spermatophyta

;

Micrococcaceae

;

Micrococcales

;

Bacteria

;

Localisation / Location

INIST-CNRS, Cote INIST : 7415, 35400004362852.0040

Nº notice refdoc (ud4) : 3094896



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