Titre du document / Document title

Fatal zipeprol and dextromethorphan poisonings in Korea

Auteur(s) / Author(s)

YOO Y. ⁽¹⁾ ; CHUNG H. ⁽¹⁾ ; KIM E. ⁽¹⁾ ; KIM M. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ National Institute of Scientific Investigation, 331-1 Shinwol-dong, Yangchon-ku, Seoul 158-097, COREE, REPUBLIQUE DE

Résumé / Abstract

Zipeprol and dextromethorphan are abused together by young people in Korea to obtain a stronger hallucinogenic effect. Because large amounts of these drugs are taken for this reason, nine fatal poisonings due to zipeprol and dextromethorphan have been reported since 1993. In this paper, the concentration of drugs in the postmortem blood and gastric contents of these victims is examined. The determination and identification of the drugs in biological fluids were conducted by gas chromatography (GC)-thermionic specific detection and GC-mass spectrometry. Linear calibration curves and high recoveries were obtained. The blood concentrations of zipeprol varied from 1.3 to 28.6 μg/mL, and the concentrations of dextromethorphan ranged from 1.1 to 18.3 μg/mL. The concentration of zipeprol in the gastric contents ranged from 26.8 to 1384.8 μg/g, and dextromethorphan concentrations varied from 2.1 to 243.7 μg/g.

Revue / Journal Title

Journal of analytical toxicology   ISSN 0146-4760   CODEN JATOD3 

Source / Source

1996, vol. 20, n^o3, pp. 155-158 (8 ref.)

Langue / Language

Anglais

Editeur / Publisher

Preston, Niles, IL, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Drug of abuse ; Hallucinogen ; Drug intoxication ; Overdosing ; Korea ; Death ; Postmortem ; Human ; Quantitative analysis ; Biological fluid ; Blood ; Epidemiology ; Gastric juice ; Gas chromatography ; Mass spectrometry ; Asia ;

Mots-clés français / French Keywords

Zipéprol ; Dextrométhorphane ; Substance toxicomanogène ; Hallucinogène ; Intoxication médicamenteuse ; Surdosage ; Corée ; Mort ; Postmortem ; Homme ; Analyse quantitative ; Liquide biologique ; Sang ; Epidémiologie ; Liquide gastrique ; Chromatographie phase gazeuse ; Spectrométrie masse ; Asie ;

Mots-clés espagnols / Spanish Keywords

Sustancia toxicomanógena ; Alucinógeno ; Intoxicación medicamentosa ; Sobredosificación ; Corea ; Muerte ; Postmortem ; Hombre ; Análisis cuantitativo ; Líquido biológico ; Sangre ; Epidemiología ; Jugo gástrico ; Cromatografía fase gaseosa ; Espectrometría masa ; Asia ;

Localisation / Location

INIST-CNRS, Cote INIST : 17415, 35400004358025.0030