Titre du document / Document title

Buspirone in the treatment of alcohol dependence : A placebo-controlled trial

Auteur(s) / Author(s)

MALEC E. ; MALEC T. ; GAGNE M. A. ; DONGIER M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Douglas Hospital Research Center, Alcohol Research Program, Montreal, Quebec, CANADA

Résumé / Abstract

A double-blind controlled study of the effects of buspirone on alcohol dependence and associated symptoms in ambulatory alcoholics showed a marked improvement in both treatment and control groups. However, significant differences in favor of the medication were observed in several psychopathological measures, but not in measures of alcohol consumption. Contrary to a majority of prior controlled trials of buspirone in alcoholics, subjects were not selected on the basis of comorbid generalized anxiety ; rather, the study tested the hypothesis of a direct effect on craving and consumption, independent from an anxiolytic effect. This hypothesis was not confirmed.

Revue / Journal Title

Alcoholism, clinical and experimental research   ISSN 0145-6008   CODEN ACRSDM 

Source / Source

1996, vol. 20, n^o2, pp. 307-312 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott Williams & Wilkins, Baltimore, MD, ETATS-UNIS  (1977) (Revue)

Mots-clés anglais / English Keywords

Alcoholism ; Human ; Ambulatory ; Treatment ; Chemotherapy ; Antialcohol drug ; Double blind study ; Tranquillizer ; Mechanism of action ;

Mots-clés français / French Keywords

Alcoolisme ; Homme ; Ambulatoire ; Traitement ; Chimiothérapie ; Antialcoolique ; Buspirone ; Etude double insu ; Tranquillisant ; Mécanisme action ;

Mots-clés espagnols / Spanish Keywords

Alcoholismo ; Hombre ; Ambulatorio ; Tratamiento ; Quimioterapia ; Antialcohólico ; Estudio doble ciego ; Tranquilizante ; Mecanismo acción ;

Localisation / Location

INIST-CNRS, Cote INIST : 17114, 35400004449022.0160