Titre du document / Document title

Treatment of photodamaged skin with trichloroacetic acid and topical tretinoin

Auteur(s) / Author(s)

HUMPHREYS T. R. ⁽¹⁾ ; WERTH V. ⁽¹⁾ ; DZUKOW L. ⁽¹⁾ ; KLIGMAN A. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, ETATS-UNIS

Résumé / Abstract

Background : Photodamaged skin typically displays lentigines, actinic keratoses, wrinkles, and textural alteration. Chemical peeling has been used to treat these, but few controlled studies have been performed to determine its efficacy. Objective : Our purpose was to compare the efficacy of a medium-depth chemical peel with and without tretinoin before and after treatment. Methods : Sixteen men with actinic damage including actinic keratoses were treated with a 40% trichloroacetic acid (TCA) chemical peel. Half were pretreated for 6 weeks with topical tretinoin ; they also used tretinoin after the peel. Photographs were obtained at baseline and at 6 weeks and 6 months after treatment. Changes in specific features were rated by a panel of three examiners. Results : Some improvement was noted in all patients. More rapid and even frosting was observed in the patients pretreated with tretinoin. Solar lentigines, actinic keratoses, and skin texture were the features of photoaging most affected ; wrinkles were least affected. No statistically significant difference was found between patients treated with TCA and tretinoin (before and after peel) and those with TCA alone. Conclusion : A medium-depth chemical peel with 40% TCA alone produced moderate improvement in some manifestations of actinic damage but had little effect on wrinkles. Treatment with tretinoin before and after TCA did not significantly enhance the efficacy of the peel.

Revue / Journal Title

Journal of the American Academy of Dermatology   ISSN 0190-9622   CODEN JAADDB 

Source / Source

1996, vol. 34, n^o4, pp. 638-644 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1979) (Revue)

Mots-clés anglais / English Keywords

Photodermatosis ; Skin peeling ; Local administration ; Topical administration ; Comparative study ; Treatment ; Chemotherapy ; Human ; Pretreatment ; Combined treatment ; Treatment efficiency ; Skin disease ; Photosensitivity ;

Mots-clés français / French Keywords

Dermatose actinique ; Peeling ; Trétinoïne ; Voie locale ; Voie externe ; Etude comparative ; Traitement ; Chimiothérapie ; Homme ; Prétraitement ; Traitement associé ; Efficacité traitement ; Acétique acide(trichloro) ; Peau pathologie ; Photosensibilité ;

Mots-clés espagnols / Spanish Keywords

Dermatitis actínica ; Peladura ; Vía local ; Vía externa ; Estudio comparativo ; Tratamiento ; Quimioterapia ; Hombre ; Pretratamiento ; Tratamiento asociado ; Eficacia tratamiento ; Piel patología ; Fotosensibilidad ;

Localisation / Location

INIST-CNRS, Cote INIST : 18387, 35400004467347.0090