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Titre du document / Document title

Effects of the quinoline derivatives quinine, quinidine, and chloroquine on neuromuscular transmission

Auteur(s) / Author(s)

SIEB J. P. (1) ; MILONE M. (1) ; ENGEL A. G. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Neurology and Neuromuscular Research Laboratory, Mayo Clinic, Rochester, MN 55905, ETATS-UNIS

Résumé / Abstract

The quinoline derivatives quinine, its stereoisomer quinidine, and chloroquine may worsen or provoke disorders of neuromuscular transmission. In this study, we investigate effects of these drugs on neuromuscular transmission by conventional microelectrode as well as patch-clamp techniques. At 5 X 10-5 M, quinine, quinidine, and chloroquine reduced the quantal content of the end-plate potential by 37-45%. Between 10-6 and 10-4 M, all 3 drugs progressively decreased the amplitude and decay time constant of miniature end-plate potential (MEPP) and miniature end-plate current (MEPC) ; at 5 X 10-3 M, the MEPP became undetectable. The effect on the MEPP was not reversed by 1 μg/ml neostigmine. Single-channel patch-clamp analysis of the effects of quinine showed that this agent causes a long-lived open-channel as well as a closed-channel block of AChR. Tests for competitive inhibition or desensitization of the acetylcholine receptor (AChR) by quinine in concentrations that had a marked effect on the MEPC and on single-channel open and closed intervals were negative. Because quinoline drugs adversely affect both presynaptic and postsynaptic aspects of neuromuscular transmission at concentrations close to those employed in clinical practice, they should not be used, or used with caution, in disorders that compromise the safety margin of neuromuscular transmission.

Revue / Journal Title

Brain research    ISSN  0006-8993   CODEN BRREAP 

Source / Source

1996, vol. 712, no2, pp. 179-189 (69 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Amsterdam, PAYS-BAS  (1966) (Revue)

Mots-clés anglais / English Keywords

Neuromuscular transmission

;

Quinolone derivative

;

Quinine

;

Patch clamp method

;

Cholinergic receptor

;

Rat

;

Mouse

;

Rodentia

;

Mammalia

;

Vertebrata

;

Electrophysiology

;

Mots-clés français / French Keywords

Transmission neuromusculaire

;

Quinolone dérivé

;

Quinine

;

Chloroquine

;

Quinidine

;

Méthode patch clamp

;

Récepteur cholinergique

;

Rat

;

Souris

;

Rodentia

;

Mammalia

;

Vertebrata

;

Electrophysiologie

;

Mots-clés espagnols / Spanish Keywords

Transmisión neuromuscular

;

Quinolone derivado

;

Método patch clamp

;

Receptor colinérgico

;

Rata

;

Ratón

;

Rodentia

;

Mammalia

;

Vertebrata

;

Electrofisiología

;

Localisation / Location

INIST-CNRS, Cote INIST : 12895, 35400004475365.0020

Nº notice refdoc (ud4) : 3030442



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