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Titre du document / Document title

Chemical pleurodesis with doxycycline 1 g

Auteur(s) / Author(s)

HERRINGTON J. D. (1) ; GORA-HARPER M. L. (1) ; SALLEY R. K. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Department of Pharmacy, University of Kentucky Chandler Medical Center, Lexington, Kentucky, ETATS-UNIS

Résumé / Abstract

We evaluated the utility of a single 1-g dose of doxycycline in the treatment of malignant and nonmalignant pleural effusions and refractory pneumothoraces in 27 consecutive patients requiring pleurodesis. After the evacuation of all retained air or fluid, and premedication with intravenous narcotic analgesics and intrapleural lidocaine 200 mg, the patients received doxycycline 1 g in 50 ml normal saline instilled through the chest tube. This was followed by instillation of 100-200 ml of air to facilitate dispersion. The chest tube was removed when the drainage was less than 150 ml/day. Twenty-three of 27 patients were evaluated at 30 days. Six (67%) of the nine patients with pneumothoraces achieved a response, and both patients with nonmalignant pleural effusions had a complete response. Of the 12 patients with malignant pleural effusion, 8 (67%) achieved a complete response, 2 had a partial response, and 2 had no response. Twenty-two (81%) of 27 patients experienced adverse effects with pleurodesis, with pain (81%) and fever (11%) being the most prevalent. In this limited number of patients, doxycycline 1 g appeared to be safe and effective for the treatment of pleural effusions and pneumothoraces. The 1-g dose must be compared with the standard 500-mg dose and with other established agents.

Revue / Journal Title

Pharmacotherapy    ISSN  0277-0008   CODEN PHPYDQ 

Source / Source

1996, vol. 16, no2, pp. 280-285 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Pharmacotherapy, Boston, MA, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Antibiotic

;

Antibacterial agent

;

Pleurisy

;

Chemotherapy

;

Pneumothorax

;

Treatment

;

Single dose

;

Human

;

Tetracycline derivatives

;

Effusion

;

Respiratory disease

;

Pleural disease

;

Mots-clés français / French Keywords

Doxycycline

;

Antibiotique

;

Antibactérien

;

Pleurésie

;

Chimiothérapie

;

Pneumothorax

;

Traitement

;

Dose unique

;

Homme

;

Tétracycline dérivé

;

Epanchement

;

Appareil respiratoire pathologie

;

Plèvre pathologie

;

Mots-clés espagnols / Spanish Keywords

Antibiótico

;

Antibacteriano

;

Pleuresía

;

Quimioterapia

;

Neumotórax

;

Tratamiento

;

Dosis única

;

Hombre

;

Tetraciclina derivado

;

Derrame

;

Aparato respiratorio patología

;

Pleura patología

;

Localisation / Location

INIST-CNRS, Cote INIST : 19165, 35400004501103.0140

Nº notice refdoc (ud4) : 3023233



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