Titre du document / Document title

Lamivudine or stabudine in two- and three-drug combinations against human immunodeficiency virus type 1 replication in vitro

Auteur(s) / Author(s)

MERRILL D. P. ; MOONIS M. ; TING-CHAO CHOU ; HIRSCH M. S. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Harvard medical school, Massachusetts gen. hosp., infectious disease unit, Boston MA, ETATS-UNIS

Résumé / Abstract

Two- and three-drug combinations of lamivudine or stavudine with other antiretroviral drugs were evaluated for activity against human immunodeficiency virus type 1 (HIV-1) activity in peripheral blood mononuclear cells. Other agents included zidovudine, didanosine, nevirapine, and saquinavir. Paired zidovudine-sensitive and -resistant clinical HIV-1 isolates were used. Additive or synergistic interactions were observed against the zidovudine-sensitive isolate with the following combinations : lamivudine-zidovudine, lamivudine-stavudine, lamivudine-saquinavir, lamivudine-nevirapine, stavudine-zidovudine, stavudine-didanosine, stavudine-saquinavir, stavudine-nevirapine, lamivudine-zidovudine-saquinavir, lamivudine-zidovudine-stavudine, stavudine-zidovudine-nevirapine, lamivudine-zidovudine-nevirapine, and stavudine-zidovudine-saquinavir. Against the zidovudine-resistant isolate, additive or synergistic interactions were seen with most two- and three-drug combinations, but the combination of stavudine-zidovudine was antagonistic. The clinical implications of these in vitro observations should be explored.

Revue / Journal Title

The Journal of infectious diseases   ISSN 0022-1899   CODEN JIDIAQ 

Source / Source

1996, vol. 173, n^o2, pp. 355-364 (51 ref.)

Langue / Language

Anglais

Editeur / Publisher

University of Chicago Press, Chicago, IL, ETATS-UNIS  (1904) (Revue)

Mots-clés anglais / English Keywords

Antiviral ; Biological activity ; HIV-1 virus ; Replication ; Drug combination ; Human ; In vitro ; Dideoxynucleoside ; Pyrimidine nucleoside ; Human immunodeficiency virus ; Lentivirinae ; Retroviridae ; Virus ;

Mots-clés français / French Keywords

Stavudine ; Antiviral ; Activité biologique ; Virus HIV1 ; Réplication ; Association médicamenteuse ; Homme ; In vitro ; Lamivudine ; Didésoxynucléoside ; Pyrimidine nucléoside ; Virus immunodéficience humaine ; Lentivirinae ; Retroviridae ; Virus ;

Mots-clés espagnols / Spanish Keywords

Antiviral ; Actividad biológica ; HIV-1 virus ; Replicación ; Asociación medicamentosa ; Hombre ; In vitro ; Didesoxinucleósido ; Pirimidina nucleósido ; Human immunodeficiency virus ; Lentivirinae ; Retroviridae ; Virus ;

Localisation / Location

INIST-CNRS, Cote INIST : 2052, 35400005270021.0110