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Titre du document / Document title

Prognosis of orbital lymphoid hyperplasia

Auteur(s) / Author(s)

POLITO E. ; LECCISOTTI A. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Siena, dep. opthalmology neurosurgery, orbital adnexal serv., Siena, ITALIE

Résumé / Abstract

Background : Orbital lymphoid hyperplasia can be associated with systemic non-Hodgkin lymphoma (NHL), even when polyclonal proliferation is found in the orbit. Although irradiation is recommended, some orbital lymphoid hyperplasias are treated by steroids (when inflammation is clinically presumed) or left untreated. . Methods : The incidence of concurrent NHL and the incidence of future NHL after oral prednisone, radiotherapy, or no treatment were retrospectively evaluated in 33 cases of lymphoid hyperplasia (22 benign lymphoid hyperplasias, BLH, and 11 atypical lymphoid hyperplasias, ALH), after follow-up of 2-13 years.. Results : NHL occurred in 12 of 33 cases (36.4%). In seven patients it was concurrent ; in five patients it occurred 2-6 years later. In the actuarial curve, at 5 years 55% of patients were free of lymphoma, at 10 years, 46%. NHL was more commonly observed when the lacrimal gland was involved (57% vs 21% ; P=0.03). Of the 13 patients treated with oral steroids, 46% had complete response, 39% partial response, and 15% future NHL. Of the seven irradiated patients, five (71%) had complete response, two (29%) partial response, and none future NHL. Of the eight untreated patients, five (63%) had partial response and three (37%) future NHL. Irradiated lacrimal gland BLHs only achieved partial response, one having radiation-induced orbital inflammation.. Conclusion : Because of a high risk of NHL, in all orbital lymphoid tumors systemic staging and follow-up are mandatory. The advised management is irradiation, except for Sjögren syndrome, an initially inflammatory lacrimal gland BLH, where a course of steroid is suggested before considering radiotherapy.

Revue / Journal Title

Graefe's archive for clinical and experimental ophthalmology    ISSN  0721-832X   CODEN GACODL 

Source / Source

1996, vol. 234, no3, pp. 150-154 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Springer, Berlin, ALLEMAGNE  (1982) (Revue)

Mots-clés anglais / English Keywords

Lymphoid hyperplasia

;

Orbit(eye)

;

Non Hodgkin lymphoma

;

Radiotherapy

;

Chemotherapy

;

Complication

;

Incidence

;

Treatment

;

Human

;

Corticosteroid

;

Antiinflammatory agent

;

Orbit(eye) disease

;

Eye disease

;

Malignant hemopathy

;

Lymphoproliferative syndrome

;

Mots-clés français / French Keywords

Hyperplasie lymphoïde

;

Orbite(oeil)

;

Lymphome non hodgkinien

;

Radiothérapie

;

Chimiothérapie

;

Complication

;

Incidence

;

Traitement

;

Homme

;

Corticostéroïde

;

Antiinflammatoire

;

Orbite(oeil) pathologie

;

Oeil pathologie

;

Hémopathie maligne

;

Lymphoprolifératif syndrome

;

Mots-clés espagnols / Spanish Keywords

Hiperplasia linfoidea

;

Orbita(ojo)

;

Linfoma no Hodgkin

;

Radioterapia

;

Quimioterapia

;

Complicación

;

Incidencia

;

Tratamiento

;

Hombre

;

Corticoesteroide

;

Antiinflamatorio

;

Orbita(ojo) patología

;

Ojo patología

;

Hemopatía maligna

;

Linfoproliferativo síndrome

;

Localisation / Location

INIST-CNRS, Cote INIST : 4847, 35400005209169.0020

Nº notice refdoc (ud4) : 2977030



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