Titre du document / Document title

Pantoprazole and omeprazole in the treatment of reflux oesophagitis : an European multicentre study

Auteur(s) / Author(s)

European Pantoprazole Study Group, EUROPE
CORINALDESI R. ⁽¹⁾ ; VALENTINI M. ; BELAÏCHE J. ; COLIN R. ; GELDOF H. ; MAIER C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Osp. S Orsalo, 40138 Bologna, ITALIE

Résumé / Abstract

Background : Pantoprazole is a new substituted benzimidazole which inhibits gastric H+,K⁺-ATPase. Methods : In this double-blind, multicentre study, pantoprazole 40 mg once daily was compared with omeprazole 20 mg once daily in the treatment of grade II and III (Savary-Miller) reflux oesophagitis. Endoscopy was repeated after 4 weeks of treatment, and also after 8 weeks in patients unhealed at 4 weeks. Results : The primary efficacy variable was ulcer healing ; after 4 weeks, 81/103 (78.6%) patients in the pantoprazole group and 83/105 (79.0%) patients in the omeprazole group had healed completely. After 8 weeks, the cumulative healing rates were 94.2% and 91.4% in the pantoprazole and omeprazole groups, respectively (P > 0.05 at 4 weeks and 8 weeks). Both groups experienced rapid relief of the key symptoms : heartburn, acid regurgitation and pain on swallowing. The time course of relief of the individual symptoms was similar in both groups after 2 and 4 weeks (P > 0.05). Both treatments were well tolerated, with only three patients withdrawing owing to adverse events. Conclusion : Pantoprazole has been shown to be as effective as omeprazole in the treatment of reflux oesophagitis.

Revue / Journal Title

Alimentary pharmacology & therapeutics   ISSN 0269-2813 

Source / Source

1995, vol. 9, n^o6, pp. 667-671 (19 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Oxford, ROYAUME-UNI  (1987) (Revue)

Mots-clés anglais / English Keywords

Comparative study ; Gastroesophageal reflux ; Esophagitis ; Chemotherapy ; Treatment ; Human ; Antisecretory agent ; Enzyme inhibitor ; Benzimidazole derivatives ; H⁺/K⁺-exchanging ATPase ; Digestive diseases ; Esophageal disease ; Hydrolases ; Enzyme ;

Mots-clés français / French Keywords

Pantoprazole ; Oméprazole ; Etude comparative ; Reflux gastrooesophagien ; Oesophagite ; Chimiothérapie ; Traitement ; Homme ; Antisécrétoire ; Inhibiteur enzyme ; Benzimidazole dérivé ; H⁺/K⁺-exchanging ATPase ; Appareil digestif pathologie ; Oesophage pathologie ; Hydrolases ; Enzyme ;

Mots-clés espagnols / Spanish Keywords

Estudio comparativo ; Reflujo gastroesofágico ; Esofagitis ; Quimioterapia ; Tratamiento ; Hombre ; Antisecretorio ; Inhibidor enzima ; Benzimidazol derivado ; H⁺/K⁺-exchanging ATPase ; Aparato digestivo patología ; Esófago patología ; Hydrolases ; Enzima ;

Localisation / Location

INIST-CNRS, Cote INIST : 21831, 35400005252011.0120