Titre du document / Document title

The effect of regular inhaled albuterol on exercise-induced bronchoconstriction

Auteur(s) / Author(s)

INMAN M. D. ; O'BYRNE P. M. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

McMaster univ., dep. medicine, asthma res. group, Hamilton ON L8N 3Z5, CANADA

Résumé / Abstract

Pretreatment with inhaled β₂-agonists is often recommended for the prevention of exercise-induced bronchoconstriction. Regular treatment with inhaled β₂-agonists has been associated with worsened baseline airway caliber and increased airway responsiveness. In this study, we have investigated the effects of regular inhaled albuterol on the severity of exercise-induced bronchoconstriction using a double-blind, placebo-controlled, randomized, crossover design. Ten subjects inhaled either albuterol or placebo (2 x 100 μg, four times per day) for 7 d. On the eighth and ninth days of treatment periods, subjects performed 5-min constant work rate cycle ergometry exercise challenges after inhaling 200 μg of placebo (eighth day) or albuterol (ninth day). Forced expired volume in 1 s (FEV₁) was measured on arrival in the laboratory as well as before and for 1 h after exercise. One week of regular inhaled albuterol compared with placebo resulted in : (1) a lower baseline FEV₁ (mean difference, 230 ml)(p = 0.02) ; (2) a lower minimum postexercises FEV₁ without inhaled albuterol pretreatment (mean difference, 390 ml ; range, -50 ml to 1,250 ml)(p = 0.01) ; (3) a lower minimum postexercise FEV₁ with inhaled albuterol pretreatment (p < 0.01). The smallest degree of exercise-induced bronchoconstriction occurred after a week of regular placebo and pretreatment with inhaled albuterol immediately before exercise. Inhalation of albuterol four times daily for 1 wk worsens exercise-induced bronchoconstriction; however, it remains extremely effective when used immediately before exercise for preventing bronchoconstriction.

Revue / Journal Title

American journal of respiratory and critical care medicine   ISSN 1073-449X 

Source / Source

1996, vol. 153, n^o1, pp. 65-69 (30 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Lung Association, New York, NY, ETATS-UNIS  (1994) (Revue)

Mots-clés anglais / English Keywords

Asthma ; Physical exercise ; β-Adrenergic receptor agonist ; β2-Adrenergic receptor ; Treatment ; Treatment efficiency ; Human ; Respiratory disease ; Bronchodilator ; Chemotherapy ; Inhalation ; Administration schedule ; Long term ;

Mots-clés français / French Keywords

Asthme ; Exercice physique ; Stimulant β-adrénergique ; Récepteur β2-adrénergique ; Traitement ; Efficacité traitement ; Homme ; Albutérol ; Appareil respiratoire pathologie ; Bronchodilatateur ; Chimiothérapie ; Inhalation ; Rythme administration ; Long terme ;

Mots-clés espagnols / Spanish Keywords

Asma ; Ejercicio físico ; Estimulante β-adrenérgico ; Receptor β2-adrenérgico ; Tratamiento ; Eficacia tratamiento ; Hombre ; Aparato respiratorio patología ; Broncodilatador ; Quimioterapia ; Inhalación ; Ritmo administración ; Largo plazo ;

Localisation / Location

INIST-CNRS, Cote INIST : 2013, 35400005206470.0040