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Titre du document / Document title

Melanin, melatonin, melanocyte-stimulating hormone, and the susceptibility to autoimmune demyelination : a rationale for light therapy in multiple sclerosis

Auteur(s) / Author(s)

CONSTANTINESCU C. S. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Univ. Pennsylvania, dep. neurology, Philadelphia PA 19104, ETATS-UNIS

Résumé / Abstract

Multiple sclerosis is a central nervous system demyelinating disease. Significant evidence, including similarities with its animal model, experimental autoimmmune encephalomyelitis, supports an autoimmune mechanism, activated by putative environmental factors in genetically predisposed individuals. Genetic factors strongly influence the susceptibility to demyelinating diseases in humans and rodents. Understanding the mechanisms governing susceptibility versus resistance may help to identify individuals at risk or design therapeutic strategies. The hypothesis formulated here is based on the observation that resistance to multiple sclerosis and experimental autoimmune encephalomyelitis is associated with dark skin pigmentation. While this may signify a protective role for melanin against environmental factors producing oxidative damage, the mechanism postulated here is that susceptibility to autoimmune demyelination is influenced by hormonal factors, i.e. the neurohormones melatonin and melanocyte stimulating hormone, which have opposing effects on immune functions and, at the same time, are important determinants of the individual's production of melanin.

Revue / Journal Title

Medical hypotheses    ISSN  0306-9877 

Source / Source

1995, vol. 45, no5, pp. 455-458 (38 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Kidlington, ROYAUME-UNI  (1975) (Revue)

Mots-clés anglais / English Keywords

Multiple sclerosis

;

Treatment

;

Melanin

;

Melatonine

;

MSH

;

Autoimmune disease

;

Adult

;

Pathogenesis

;

Animal

;

Nervous system diseases

;

Central nervous system disease

;

Inflammatory disease

;

Human

;

Mots-clés français / French Keywords

Sclérose en plaque

;

Traitement

;

Mélanine

;

Mélatonine

;

MSH

;

Maladie autoimmune

;

Adulte

;

Pathogénie

;

Animal

;

Système nerveux pathologie

;

Système nerveux central pathologie

;

Maladie inflammatoire

;

Homme

;

Mots-clés espagnols / Spanish Keywords

Esclerosis en placa

;

Tratamiento

;

Melanina

;

Melatonina

;

MSH

;

Enfermedad autoinmune

;

Adulto

;

Patogenia

;

Animal

;

Sistema nervioso patología

;

Sistema nervosio central patología

;

Enfermedad inflamatoria

;

Hombre

;

Localisation / Location

INIST-CNRS, Cote INIST : 18253, 35400005522603.0080

Nº notice refdoc (ud4) : 2941597



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