Titre du document / Document title
Royal jelly, a possible agent to reduce the nicotine-induced atherogenic lipoprotein profile
Auteur(s) / Author(s)
ABOU-HOZAIFA B. M. (1) ;
BADR EL-DIN N. K. ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) King Faisal univ., dep. physiology, Dammam 31451, ARABIE SAOUDITE
Résumé / Abstract
Objective : The study investigated the effect of royal jelly on the nicotine-induced atherogenic lipoprotein profile. Design : To evaluate the changes in lipid and lipoprotein cholesterol concentrations, royal jelly (1 mg/g body weight/day) and/or nicotine (0.05 mg/ml in drinking water, a dose which simulated intake by heavy smokers) were tested in adult male rats, following 8 weeks of their oral supplementation. Results : Neither royal jelly nor nicotine or their combination significantly changed serum total cholesterol and triglyceride levels. Additionally royal jelly did not significantly change serum lipoprotein cholesterol concentrations. Oral nicotine alone progressively inhibited weight gain and significantly lowered the high density lipoprotein cholesterol level and its ratio to the total cholesterol (by 19% and 23% respectively). Also nicotine elevated the low density lipoprotein/high density lipoprotein (LDL/HDL) cholesterol ratio (82%) significantly. On the other hand, royal jelly when given to nicotine treated rats increased the HDL cholesterol and HDL/total cholesterol ratio and decreased the LDL/HDL cholesterol ratio to reach values insignificantly different from the control. Royal jelly also prevented the progressive decline in body weight gain caused by nicotine administration. Conclusion : Our data demonstrated that royal jelly is a potential antiatherosclerotic agent capable of improving the nicotine-induced atherogenic lipoprotein profile.
Revue / Journal Title
Saudi medical journal
ISSN
0379-5284
CODEN SAMJDI
Source / Source
1995, vol. 16, n
o4, pp. 337-342 (40 ref.)
Langue / Language
Anglais
Editeur / Publisher
Saudi Medical Journal, Riyadh, ARABIE SAOUDITE
(1979)
(Revue)
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Localisation / Location
INIST-CNRS, Cote INIST : 19973, 35400005511721.0150
Nº notice refdoc (ud4) : 2939519
