Titre du document / Document title

The anti-Malassezia furfur activity in vitro and in experimental dermatitis of six imidazole antifungal agents : bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole = Die Aktivität von sechs Imidazol-Antimykotika (Bifonazol, Clotrimazol, Flutrimazol, Ketoconazol, Miconazol und Sertaconazol) gegen Malassezia furfur in vitro und bei experimenteller Dermatitis

Auteur(s) / Author(s)

VAN GERVEN F. ; ODDS F. C. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Janssen res. foundation, dep. bacteriology mycology, 2340 Beerse, BELGIQUE

Résumé / Abstract

Bifonazole, clotrimazole, flutrimazole, ketoconazole, miconazole and sertaconazole were tested for their activity against 23 isolates of Malassezia furfur by agar dilution in vitro. Topical formulations of the same agents were evaluated for efficacy against M. furfur skin infections in guinea pigs in vivo. The most potent inhibitor in vitro was ketoconazole (geometric mean minimum inhibitory concentration 0.51 μg ml^-1), followed by bifonazole (8.1 μg ml^-1), then miconazole (14 μg ml^-1), clotrimazole (15 μg ml^-1) and flutrimazole (16 μg ml^-1), with sertaconazole the least active (52 μg ml^-1). In animal experiments involving three consecutive days of topical treatments, bifonazole 1% cream, clotrimazole 1% cream, flutrimazole 1% and 2% creams, ketoconazole 2% cream and shampoo and miconazole 2% cream all reduced M. furfur dermatitis lesion severity below that of untreated control animals ; however, sertaconazole 2% gel and cream showed no reduction in lesion severity below control. The results confirm that ketoconazole is a more potent inhibitor of M. furfur in vitro than other topical antifungal agents of its class and suggest that sertaconazole is the least effective of such agents among those tested.

Revue / Journal Title

Mycoses   ISSN 0933-7407 

Source / Source

1995, vol. 38, n^o9-10, pp. 389-393 (16 ref.)

Langue / Language

Anglais

Editeur / Publisher

Blackwell, Berlin, ALLEMAGNE  (1988) (Revue)

Mots-clés anglais / English Keywords

Sensitivity resistance ; Drug susceptibility test ; Antifungal agent ; In vitro ; Malassezia furfur ; Imidazole derivatives ; Fungi Imperfecti ; Fungi ; Thallophyta ;

Mots-clés français / French Keywords

Sensibilité résistance ; Test sensibilité médicamenteuse ; Antifongique ; In vitro ; Malassezia furfur ; Imidazole dérivé ; Clotrimazole ; Bifonazole ; Flutrimazole ; Kétoconazole ; Miconazole ; Sertaconazole ; Fungi Imperfecti ; Fungi ; Thallophyta ;

Mots-clés espagnols / Spanish Keywords

Sensibilidad resistencia ; Prueba sensibilidad medicamentosa ; Antifúngico ; In vitro ; Malassezia furfur ; Imidazol derivado ; Fungi Imperfecti ; Fungi ; Thallophyta ;

Localisation / Location

INIST-CNRS, Cote INIST : 4156 B, 35400005913695.0090