Titre du document / Document title

Intranasal butorphanol-induced apraxia reversed by naloxone

Auteur(s) / Author(s)

GORA-HARPER M. L. ⁽¹⁾ ; SUNAHARA J. F. ; GRAY M. S. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Univ. Kentucky medical cent., div. pharmacy practice sci., Lexington KY, ETATS-UNIS

Résumé / Abstract

Intranasal butorphanol is an opioid agonist-antagonist that is effective for the treatment of acute pain. Common adverse effects associated with the agent are somnolence, dizziness, nausea, and vomiting ; they are readily reversed with naloxone. A patient developed signs and symptoms consistent with apraxia after a single dose of intranasal butorphanol. She was mentally alert, but she was unable to move or speak despite normal muscle tone and reflex movements. When she attempted to speak she had no voluntary control. At the emergency room she was administered naloxone 2 mg intramuscularly, which resulted in complete reversal of the symptoms in a short time. No other published cases describe these findings with butorphanol. Health care professionals should be aware that patients who are prescribed intranasal butorphanol, even in typical doses, may be at risk for such a reaction. This is important because, unlike the injectable formulation, the intranasal product is primarily used in the outpatient setting.

Revue / Journal Title

Pharmacotherapy   ISSN 0277-0008   CODEN PHPYDQ 

Source / Source

1995, vol. 15, n^o6, pp. 798-800 (10 ref.)

Langue / Language

Anglais

Editeur / Publisher

Pharmacotherapy, Boston, MA, ETATS-UNIS  (1981) (Revue)

Mots-clés anglais / English Keywords

Intranasally administration ; Apraxia ; Chemotherapy ; Treatment ; Toxicity ; Narcotic analgesic ; Human ; Case study ; Opiates ; Morphinan derivatives ; Nervous system diseases ; Central nervous system disease ; Cerebral disorder ; Neurological disorder ;

Mots-clés français / French Keywords

Butorphanol ; Voie intranasale ; Naloxone ; Apraxie ; Chimiothérapie ; Traitement ; Toxicité ; Analgésique narcotique ; Homme ; Etude cas ; Opiacés ; Morphinane dérivé ; Système nerveux pathologie ; Système nerveux central pathologie ; Encéphale pathologie ; Trouble neurologique ;

Mots-clés espagnols / Spanish Keywords

Vía intranasal ; Apraxia ; Quimioterapia ; Tratamiento ; Toxicidad ; Analgésico narcotico ; Hombre ; Estudio caso ; Opiados ; Sistema nervioso patología ; Sistema nervosio central patología ; Encéfalo patología ; Trastorno neurológico ;

Localisation / Location

INIST-CNRS, Cote INIST : 19165, 35400005899548.0190