Titre du document / Document title

Labor induction with intravaginal misoprostol versus intracervical prostaglandin E₂ gel (Prepidil gel) : randomized comparison

Auteur(s) / Author(s)

CHUCK F. J. ; HUFFAKER B. J. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Kaiser foundation hosp., dep. obstetrics gynecology, div. maternal-fetal medicine, Los Angeles CA 90027, ETATS-UNIS

Résumé / Abstract

OBJECTIVE : Our purpose was to compare the safety and efficacy of intravaginal prostaglandin E₁, misoprostol, with that of intracervical prostaglandin E₂ (Prepidil gel) for labor induction. STUDY DESIGN : One hundred three patients with an indication for induction of labor were randomly assigned to induction with prostaglandin E₁, 50 μg intravaginally, or with Prepidil gel, 0.5 mg intracervically, every 4 hours until active labor. RESULTS : Four patients were excluded, leaving 49 patients who received prostaglandin E₁ and 50 who received prostaglandin E₂. The time from start of induction to vaginal delivery was significantly shorter in the prostaglandin E₁ group (11.4 vs 18.9 hours, p < 0.001), and fewer patients in the prostaglandin E₁ group required oxytocin augmentation (23% vs 55%, p < 0.005). No significant differences were noted in mode of delivery or in adverse maternal, fetal, or neonatal effects. CONCLUSION : Intravaginal prostaglandin E₁ is a more effective, lower-cost agent for induction of labor than is intracervical prostaglandin E₂ gel and is comparable in safety.

Revue / Journal Title

American journal of obstetrics and gynecology   ISSN 0002-9378   CODEN AJOGAH 

Source / Source

Congrès
Society of Perinatal Obstetricians. Annual meeting N^o15, Atlanta GA , ETATS-UNIS (23/01/1995)
1995, vol. 173, n^o4, pp. 1137-1142 (20 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Philadelphia, PA, ETATS-UNIS  (1920) (Revue)

Mots-clés anglais / English Keywords

Delivery ; Triggering ; Induction ; Route of administration ; Prostaglandin E1 ; Prostaglandin E2 ; Colloidal gel ; Endocervix ; Human ; Female ; Complication ; Chemotherapy ;

Mots-clés français / French Keywords

Accouchement ; Déclenchement ; Induction ; Voie administration ; Prostaglandine E1 ; Prostaglandine E2 ; Gel colloïdal ; Endocol utérus ; Homme ; Femelle ; Complication ; Chimiothérapie ;

Mots-clés espagnols / Spanish Keywords

Parto ; Inducción ; Inducción ; Vía administración ; Prostaglandina E1 ; Prostaglandina E2 ; Gel coloidal ; Endocervix ; Hombre ; Hembra ; Complicación ; Quimioterapia ;

Localisation / Location

INIST-CNRS, Cote INIST : 3053, 35400005874368.0240