Titre du document / Document title

Relationships of serum estradiol levels, menopausal duration, and mood during hormonal replacement therapy

Auteur(s) / Author(s)

KLAIBER E. L. ⁽¹⁾ ; BROVERMAN D. M. ⁽²⁾ ; VOGEL W. ⁽³⁾ ; PETERSON L. G. ⁽³⁾ ; SNYDER M. B. ⁽³⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Worcester Foundation for Biomedical Research, Shrewsbury, MA, ETATS-UNIS
⁽²⁾ Worcester State Hospital, Worcester, MA, ETATS-UNIS
⁽³⁾ University of Massachusetts Medical Center, Worcester, MA, ETATS-UNIS

Résumé / Abstract

A study was undertaken in 38 menopausal women on cyclic HRT (estropipate and estropipate + norethindrone). Serum estradiol levels during treatment were related to mood changes and platelet MAO activity. The relationship between serum estradiol levels and mood changes was found to be a function of the duration of menopause. Women with a short duration of menopause (12.9 months ± 6.1) were compared to women with a long duration of menopause (76.6 months ± 52.3). Women with a short duration of menopause had significantly lower mean serum estradiol levels during HRT compared to women with a long duration of menopause (216.9±62.3 vs. 291.13 ± 118.12, respectively, p<.02). It had previously been reported that estrogen treatment in menopausal women had a positive effect on mood, whereas the combination of estrogen plus a progestin had a negative effect on mood. We found that the women with a long duration of menopause and higher treatment serum estradiol levels had significantly more dysphoria when receiving a combination of estrogen plus progestin than did the women with a short duration of menopause and lower serum estradiol levels. However, both short and long duration menopausal groups showed improvement in mood when estrogen was administered alone. Platelet MAO levels, a marker of adrenergic and serotonergic function thought to relate to mood, were negatively correlated with serum estradiol levels during HRT. We suggest that these paradoxical findings may be secondary to a prolonged estrogen deficiency state in women with a long duration of menopause.

Revue / Journal Title

Psychoneuroendocrinology   ISSN 0306-4530   CODEN PSYCDE 

Source / Source

1997, vol. 22, n^o7, pp. 549-558 (24 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, Oxford, ROYAUME-UNI  (1975) (Revue)

Mots-clés anglais / English Keywords

Menopause ; Estradiol ; Hormonal investigation ; Replacement therapy ; Mood ; Progesterone ; Duration ; Amine oxidase (flavin-containing) ; Human ; Female ; Oxidoreductases ; Enzyme ; Estrogen ; Ovarian hormone ; Sex steroid hormone ;

Mots-clés français / French Keywords

Ménopause ; Estradiol ; Exploration hormonale ; Traitement substitutif ; Humeur ; Progestérone ; Durée ; Amine oxidase (flavin-containing) ; Homme ; Femelle ; Oxidoreductases ; Enzyme ; Oestrogène ; Hormone ovarienne ; Hormone stéroïde sexuelle ;

Mots-clés espagnols / Spanish Keywords

Menopausia ; Estradiol ; Análisis hormonal ; Tratamiento sustitutivo ; Humor ; Progesterona ; Duración ; Amine oxidase (flavin-containing) ; Hombre ; Hembra ; Oxidoreductases ; Enzima ; Estrógeno ; Hormona ovárica ; Hormona esteroide sexual ;

Localisation / Location

INIST-CNRS, Cote INIST : 17200, 35400006974068.0070