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Titre du document / Document title

Pharmacology of ribosomal immunotherapy

Auteur(s) / Author(s)

CLOT J. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Laboratoire d'Immunologie, INSERM, Hôpital Saint-Eloi, Montpellier, FRANCE

Résumé / Abstract

The use of immunostimulating drugs is one way to intervene in the immune system. Many of these agents are of bacterial origin and most are able to stimulate the nonspecific immune response by acting on polymorphonuclear cells (PMNs) and macrophages. Ribosomal immunotherapy ('Ribomunyl') contains both proteoglycans from Klebsiella pneumoniae and ribosomes from 4 different bacterial strains. It can stimulate not only macrophages but also specific antibody production. 'Ribomunyl' has been shown to stimulate many of the functions of PMNs, specifically the formation of oxygenated free radicals, chemotaxis and adhesion. The effect of 'Ribomunyl' immunostimulant on the properties of macrophages is of special interest, as these cells participate in both the nonspecific immune response (phagocytosis, proinflammatory cytokine production) and the specific immune response (antigen processing and presentation, lymphocyte proliferation). 'Ribomunyl' has been shown to increase the production of many cytokines [interleukin (IL)-1, IL-6, IL-8, tumour necrosis factor-a and colony-stimulating factor], leading to the activation of the cytokine network. 'Ribomunyl' was also able to stimulate natural killer cells involved in viral immunity. Because of the presence of ribosomes from 4 frequently encountered bacterial strains, 'Ribomunyl' has specific immunostimulant properties. This has been clearly demonstrated in animals and humans, where specific antibody-forming B cells were found in the tonsils after oral administration. However, specific T-cell response has not been reported, suggesting that 'Ribomunyl' could act directly on B cells such as T-cell-independent bacterial antigens.

Revue / Journal Title

Drugs    ISSN  0012-6667   CODEN DRUGAY 

Source / Source

Congrès
Advances in Ribosomal Immunotherapy. Symposium, Cannes , FRANCE (22/05/1997)
1997, vol. 54, SUP1 (54 p.)  (17 ref.), [Notes: Communications et posters], pp. 33-36

Langue / Language

Anglais

Editeur / Publisher

Adis International, Auckland, NOUVELLE-ZELANDE  (1962) (Revue)

Mots-clés anglais / English Keywords

Ribosome

;

Immunostimulant agent

;

Immunomodulator

;

Oral administration

;

Immunotherapy

;

Mechanism of action

;

Biological activity

;

Humoral immunity

;

Immune response

;

Microbial origin

;

Bacteria

;

Mots-clés français / French Keywords

Ribosome

;

Immunostimulant

;

Immunomodulateur

;

Voie orale

;

Immunothérapie

;

Mécanisme action

;

Activité biologique

;

Immunité humorale

;

Réponse immune

;

Origine microbienne

;

Bactérie

;

Ribomunyl

;

Mots-clés espagnols / Spanish Keywords

Ribosoma

;

Inmunoestimulante

;

Inmunomodulador

;

Vía oral

;

Inmunoterapia

;

Mecanismo acción

;

Actividad biológica

;

Inmunidad humoral

;

Respuesta inmune

;

Origen microbiano

;

Bacteria

;

Localisation / Location

INIST-CNRS, Cote INIST : 15326, 35400006917166.0070

Nº notice refdoc (ud4) : 2829358



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