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Titre du document / Document title

Diagnostic approach of Rotor syndrome with cholescintigraphy

Auteur(s) / Author(s)

FRETZAYAS A. M. (1) ; STAVRINADIS C. S. (1) ; KOUKOUTSAKIS P. M. (1) ; SINANIOTIS C. A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) 2nd Department of Pediatrics, University of Athens, School of Medicine A.P. Kyriakou Children's Hospital, Athens, GRECE

Résumé / Abstract

Rotor syndrome is an inheritable disorder of bilirubin metabolism characterized by a chronic, benign, nonhemolytic jaundice, due to raised, predominantly direct bilirubin. It is considered a pathophysiologic entity primarily involving the storage of organic anions leading to increased reflux of bilirubin from the hepatocytes back to the plasma, resulting in decreased net hepatic uptake. This concept is further supported by scintigraphic findings (i.e., prolonged visualization of the cardiac blood pool with concomitant delayed and markedly decreased uptake of the radionuclide by the liver cells). Furthermore, this scintigraphic pattern differentiates Rotor syndrome from Dubin-Johnson syndrome, extrahepatic biliary obstruction, or advanced hepatocellular disease.

Revue / Journal Title

Clinical nuclear medicine    ISSN  0363-9762   CODEN CNMEDK 

Source / Source

1997, vol. 22, no9, pp. 635-636 (6 ref.)

Langue / Language

Anglais

Editeur / Publisher

Lippincott, Hagerstown, MD, ETATS-UNIS  (1976) (Revue)

Mots-clés anglais / English Keywords

Rotor disease

;

Case study

;

Adolescent

;

Scintigraphy

;

Biliary tract

;

Liver

;

Diagnosis

;

Human

;

Digestive diseases

;

Hepatic disease

;

Biliary tract disease

;

Hyperbilirubinemia

;

Genetic disease

;

Radionuclide study

;

Medical imagery

;

Mots-clés français / French Keywords

Ictère héréditaire Rotor

;

Etude cas

;

Adolescent

;

Scintigraphie

;

Voie biliaire

;

Foie

;

Diagnostic

;

Technetium 99m IDA

;

Homme

;

Appareil digestif pathologie

;

Foie pathologie

;

Voie biliaire pathologie

;

Hyperbilirubinémie

;

Maladie héréditaire

;

Exploration radioisotopique

;

Imagerie médicale

;

Mots-clés espagnols / Spanish Keywords

Ictericia hereditaria Rotor

;

Estudio caso

;

Adolescente

;

Centelleografía

;

Vía biliar

;

Hígado

;

Diagnóstico

;

Hombre

;

Aparato digestivo patología

;

Hígado patología

;

Vía biliar patología

;

Hiperbilirrubinemia

;

Enfermedad hereditaria

;

Exploración radioisotópica

;

Imageneria medical

;

Localisation / Location

INIST-CNRS, Cote INIST : 16903, 35400006921325.0130

Nº notice refdoc (ud4) : 2802899



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