Titre du document / Document title
Intravitreal ganciclovir treatment in progressive outer retinal necrosis
Auteur(s) / Author(s)
PEREZ-BLAZQUEZ E.
(1) ;
TRASPAS R.
(1) ;
MENDEZ MARIN I.
(1) ;
MONTERO M.
(1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Ophthalmology, 12 de Octubre University Hospital, ESPAGNE
Résumé / Abstract
PURPOSE: To report two patients with progressive outer retinal necrosis, which is presumed to be caused by the varicella-zoster virus in patients with acquired immunodeficiency syndrome (AIDS). METHOD: Case report. RESULTS: The patients were treated with intravenous foscarnet, 60 mg per kg of body weight three times per week, without response. Remission of retinal necrosis occurred with the commencement of intravitreal ganciclovir treatment, 400 mg two times per week. Laser photocoagulation was performed in both cases. Neither patient developed retinal detachment. CONCLUSIONS: Intravitreal ganciclovir treatment combined with systemic antiviral agent therapy in patients with progressive outer retinal necrosis may delay progress of the disease. Early photocoagulation may prevent the development of retinal detachment if retinal necrosis is controlled.
Revue / Journal Title
American journal of ophthalmology
ISSN 0002-9394
CODEN AJOPAA
Source / Source
1997, vol. 124, n
o3, pp. 418-421 (4 ref.)
Langue / Language
Anglais
Editeur / Publisher
Elsevier, New York, NY, ETATS-UNIS
(1884)
(Revue)
Mots-clés anglais / English Keywords
AIDS ;
Retinitis ;
Necrosis ;
Acute ;
Varicella zoster virus ;
Ganciclovir ;
Antiviral ;
Intravitreous administration ;
Treatment ;
Chemotherapy ;
Human ;
Case study ;
Acyclic nucleoside ;
Purine nucleoside ;
Viral disease ;
Infection ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Immunopathology ;
Immune deficiency ;
Eye disease ;
Retinopathy ;
Mots-clés français / French Keywords
SIDA ;
Rétinite ;
Nécrose ;
Aigu ;
Virus varicelle ;
Ganciclovir ;
Antiviral ;
Voie intravitréenne ;
Traitement ;
Chimiothérapie ;
Homme ;
Etude cas ;
Nucléoside acyclique ;
Purine nucléoside ;
Virose ;
Infection ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Immunopathologie ;
Immunodéficit ;
Oeil pathologie ;
Rétinopathie ;
Mots-clés espagnols / Spanish Keywords
SIDA ;
Retinitis ;
Necrosis ;
Agudo ;
Varicella zoster virus ;
Ganciclovir ;
Antiviral ;
Vía intravítrea ;
Tratamiento ;
Quimioterapia ;
Hombre ;
Estudio caso ;
Nucleósido acíclico ;
Purina nucleósido ;
Virosis ;
Infección ;
Alphaherpesvirinae ;
Herpesviridae ;
Virus ;
Inmunopatología ;
Inmunodeficiencia ;
Ojo patología ;
Retinopatía ;
Localisation / Location
INIST-CNRS, Cote INIST : 2012, 35400006921184.0270
Nº notice refdoc (ud4) : 2796981
