Titre du document / Document title

Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome

Auteur(s) / Author(s)

REGLAND B. ⁽¹⁾ ; ANDERSSON M. ⁽²⁾ ; ABRAHAMSSON L. ⁽³⁾ ; BAGBY J. ⁽²⁾ ; DYREHAG L. E. ^{(2 4)} ; GOTTFRIES C. G. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ Institute of Clinical Neuroscience, Göteborg University, SUEDE
⁽²⁾ Pain Unit, Kungälv Hospital, SUEDE
⁽³⁾ Department of Clinical Chemistry, Uddevalla Hospital, SUEDE
⁽⁴⁾ Department of Physiology, Göteborg University, SUEDE

Résumé / Abstract

Twelve outpatients, all women, who fulfilled the criteria for both fibromyalgia and chronic fatigue syndrome were rated on 15 items of the Comprehensive Psychopathological Rating Scale (CPRS-15). These items were chosen to constitute a proper neurasthenic subscale. Blood laboratory levels were generally normal. The most obvious finding was that, in all the patients, the homocysteine (HCY) levels were increased in the cerebrospinal fluid (CSF). There was a significant positive correlation between CSF-HCY levels and fatiguability, and the levels of CSF-B12 correlated significantly with the item of fatiguability and with CPRS-15. The correlations between vitamin B12 and clinical variables of the CPRS-scale in this study indicate that low CSF-B12 values are of clinical importance. Vitamin B12 deficiency causes a deficient remethylation of HCY and is therefore probably contributing to the increased homocysteine levels found in our patient group. We conclude that increased homocysteine levels in the central nervous system characterize patients fulfilling the criteria for both fibromyalgia and chronic fatigue syndrome.

Revue / Journal Title

Scandinavian journal of rheumatology   ISSN 0300-9742   CODEN SJRHAT 

Source / Source

1997, vol. 26, n^o4, pp. 301-307 (32 ref.)

Langue / Language

Anglais

Editeur / Publisher

Taylor & Francis, Colchester, ROYAUME-UNI  (1972) (Revue)

Mots-clés anglais / English Keywords

Fibromyalgia ; Chronic fatigue syndrome ; Exploration ; Concentration ; Cerebrospinal fluid ; Cyanocobalamin ; Correlation analysis ; Symptomatology ; Human ; Pain ; Diseases of the osteoarticular system ; Striated muscle disease ;

Mots-clés français / French Keywords

Fibromyalgie ; Fatigue chronique syndrome ; Exploration ; Homocystéine ; Concentration ; Liquide céphalorachidien ; Cyanocobalamine ; Analyse corrélation ; Symptomatologie ; Homme ; Douleur ; Système ostéoarticulaire pathologie ; Muscle strié pathologie ;

Mots-clés espagnols / Spanish Keywords

Fibromialgia ; Fatiga crónica síndrome ; Exploración ; Concentración ; Líquido cefalorraquídeo ; Cianocobalamina ; Análisis correlación ; Sintomatología ; Hombre ; Dolor ; Sistema osteoarticular patología ; Músculo estriado patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 4382, 35400006902564.0110