Titre du document / Document title

Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report

Auteur(s) / Author(s)

MEYTHALER J. M. ; MCCARY A. ; HADLEY M. N. ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

Department of Physical Medicine and Rehabilitation, University of Alabama School of Medicine, Birmingham, Alabama, ETATS-UNIS
Division of Neurological Surgery, University of Alabama School of Medicine, Birmingham, Alabama, ETATS-UNIS

Résumé / Abstract

Twelve consecutive patients with severe spasticity and hypertonia following acquired brain injury were treated with continuous intrathecal infusion of baclofen via an implanted, programmable infusion pump-catheter system for a minimum of 3 months. In every case intrathecal baclofen therapy resulted in a statistically significant reduction in upper-and lower-extremity tone, spasm frequency, and reflexes, contributing to improved functional abilities. There were no untoward side effects or complications associated with treatment. This preliminary assessment indicates that intrathecal administration of baclofen is effective in treating the disabling spasticity caused by acquired brain injury in selected patients.

Revue / Journal Title

Journal of neurosurgery   ISSN 0022-3085   CODEN JONSAC 

Source / Source

1997, vol. 87, n^o3, pp. 415-419 (12 ref.)

Langue / Language

Anglais

Editeur / Publisher

American Association of Neurological Surgeons, Park Ridge, IL, ETATS-UNIS  (1944) (Revue)

Mots-clés anglais / English Keywords

Spasticity ; Trauma ; Craniocerebral ; Baclofen ; Muscle relaxant ; Antispasmodic agent ; Intrathecal administration ; Continuous process ; Chemotherapy ; Pump ; Implanted ; Treatment ; Complication ; Young adult ; Human ; Striated muscle disease ; Muscle tonus alteration ; Nervous system diseases ; Neurological disorder ; Central nervous system disease ; Cerebral disorder ; Diseases of the osteoarticular system ; Skull disease ;

Mots-clés français / French Keywords

Hypertonie spastique ; Traumatisme ; Crânioencéphalique ; Baclofène ; Myorésolutif ; Spasmolytique ; Voie intrarachidienne ; En continu ; Chimiothérapie ; Pompe ; Implanté ; Traitement ; Complication ; Adulte jeune ; Homme ; Muscle strié pathologie ; Trouble tonus ; Système nerveux pathologie ; Trouble neurologique ; Système nerveux central pathologie ; Encéphale pathologie ; Système ostéoarticulaire pathologie ; Crâne pathologie ;

Mots-clés espagnols / Spanish Keywords

Hipertonia espástica ; Traumatismo ; Craneoencefálico ; Baclofeno ; Relajante muscular ; Espasmolítico ; Vía intraraquídea ; En continuo ; Quimioterapia ; Bomba ; Implantado ; Tratamiento ; Complicación ; Adulto joven ; Hombre ; Músculo estriado patología ; Trastorno tono muscular ; Sistema nervioso patología ; Trastorno neurológico ; Sistema nervosio central patología ; Encéfalo patología ; Sistema osteoarticular patología ; Cráneo patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 6023, 35400006898929.0120