Titre du document / Document title

Intracameral tissue plasminogen activator to treat severe fibrinous effusion after cataract surgery

Auteur(s) / Author(s)

WEDRICH A. ⁽¹⁾ ; MENAPACE R. ⁽¹⁾ ; RIES E. ⁽¹⁾ ; POLZER I. ⁽¹⁾ ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

⁽¹⁾ University Eye Hospital Vienna, AUTRICHE

Résumé / Abstract

Purpose: To evaluate the efficacy and complications of intracameral recombinant tissue plasminogen activator (r-tPA) in the treatment of severe fibrinous effusion after cataract and combined cataract and glaucoma surgery. Setting: University Eye Hospital Vienna, Austria. Methods: In a prospective study, 40 eyes of 39 patients with severe fibrinous anterior chamber reaction in the early postoperative course received 25 μg r-tPA intracamerally through a temporal paracentesis. The main outcome measures were rate of complete fibrinolysis, time of maximal effect, and complications. Results: Complete fibrinolysis occurred in 33 eyes (83%) after a mean of 3.2 hours ± 0.9 (SD). The rate of complete fibrinolysis was higher in eyes having cataract surgery only (24 eyes, 89%) than in those having combined surgery (9 eyes, 69%). Recurrent fibrin was seen in 3 eyes (7%), small anterior chamber hemorrhage in 7 (18%), increased intraocular pressure in 3 (7%), and posterior synechias in 13 (33%). Complications were managed conservatively. Conclusion: The intracameral injection of 25 μg r-tPA proved to be a safe, efficient, and low-risk supplement in the treatment of severe postoperative fibrinous reactions.

Revue / Journal Title

Journal of cataract and refractive surgery   ISSN 0886-3350   CODEN JCSUEV 

Source / Source

1997, vol. 23, n^o6, pp. 873-877 (22 ref.)

Langue / Language

Anglais

Editeur / Publisher

Elsevier, New York, NY, ETATS-UNIS  (1986) (Revue)

Mots-clés anglais / English Keywords

Cataract ; Glaucoma (eye) ; Surgery ; Complication ; Effusion ; Fibrin ; Alteplase ; Chemotherapy ; Treatment ; Anterior chamber ; Fibrinolytic ; Human ; Eye disease ; Lens disease ; Anterior segment disease ;

Mots-clés français / French Keywords

Cataracte ; Glaucome ; Chirurgie ; Complication ; Epanchement ; Fibrine ; Altéplase ; Chimiothérapie ; Traitement ; Chambre antérieure ; Fibrinolytique ; Homme ; Oeil pathologie ; Cristallin pathologie ; Segment antérieur pathologie ;

Mots-clés espagnols / Spanish Keywords

Catarata ; Glaucoma (ojo) ; Cirugía ; Complicación ; Derrame ; Fibrina ; Alteplasa ; Quimioterapia ; Tratamiento ; Cámara anterior ; Fibrinolítico ; Hombre ; Ojo patología ; Cristalino patología ; Segmento anterior patología ;

Localisation / Location

INIST-CNRS, Cote INIST : 20937, 35400006908975.0090