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Titre du document / Document title

Résistance périphérique à l'insuline et concentration intralymphocytaire de magnésium et de calcium ionisés chez des patients avec hypertension artérielle essentielle = Intralymphocyte free magnesium and calcium and insulin tolerance test in a group of essential hypertensive patients

Auteur(s) / Author(s)

DELVA P. (1) ; PASTORI C. (1) ; MONTESI G. (1) ; DEGAN M. (1) ; PALUANI F. (1) ; LECHI A. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Université de Verona, département de clinique médicale, Policlinico Borgo Roma, 37134 Verona, ITALIE

Résumé / Abstract

To ascertain the claimed links between peripheral insulin resistance and intracellular magnesium and calcium concentrations. we measured free intralymphocyte magnesium (Mgi) and calcium (Cai) concentrations. as well as the rate constant of plasma glucose disappearance (Kitt) after insulin injection (insulin tolerance test : ITT). in a group of 15 normotensive control subjects (NC) and 29 essential hypertensive subjects (EH). Mgi and Cai were measured in triplicate by means of a fluorimetric technique based on the dyes furaptra and fura-2 respectively. Kitt value were significantly reduced in hypertensive subjects as compared to control subjects (M ± SD, EH : 4.54 ± 1.31 vs 5.63 ± 1.07; p < 0.02; 95 % confidence limits: 0.22-1.96). Mgi and Cai were not statistically different in hypertensive subjects as compared to control subjects (Mgi, NC: 0.274 ± 0.02 mmol/L; EH: 0.248 ± 0.05 mmol/L; Cai, NC: 47.6 ± 9 mmol/L, EH: 46.7 ± 13.6 mmol/L). A statistically significant inverse correlation was found in the whole study group between Kitt and body mass index (R = -0.394, p = 0.01) and a statistically significant positive correlation between Kitt and Mgi (R = 0.386; p = 0.012). The latter correlation was no longer statistically significant if adjusted for body mass index. Our data are in favour of a link between index of peripheral insulin resistance and body mass index. A dependance from Mgi is possible but the study lack so far the statistical power to demonstrate it.

Revue / Journal Title

Archives des maladies du coeur et des vaisseaux    ISSN  0003-9683   CODEN AMCVAN 

Source / Source

1997, vol. 90, no8, pp. 1147-1149 (5 ref.)

Langue / Language

Français

Editeur / Publisher

Huveaux, Neuilly sur Seine, FRANCE  (1937-2007) (Revue)

Mots-clés anglais / English Keywords

Hypertension

;

Human

;

Target tissue resistance

;

Insulin

;

Magnesium

;

Calcium

;

Lymphocyte

;

Insulin test

;

Association

;

Cardiovascular disease

;

Endocrinopathy

;

Mots-clés français / French Keywords

Hypertension artérielle

;

Homme

;

Résistance tissu cible

;

Insuline

;

Magnésium

;

Calcium

;

Lymphocyte

;

Test insuline

;

Association

;

Appareil circulatoire pathologie

;

Endocrinopathie

;

Mots-clés espagnols / Spanish Keywords

Hipertensión arterial

;

Hombre

;

Resistencia tejido blanco

;

Insulina

;

Magnesio

;

Calcio

;

Linfocito

;

Prueba insulina

;

Asociación

;

Aparato circulatorio patología

;

Endocrinopatía

;

Localisation / Location

INIST-CNRS, Cote INIST : 887, 35400006802186.0230

Nº notice refdoc (ud4) : 2774410



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